About Enhancer
| Enhancer ID: | E_02_0006 |
| Species: | mouse |
| Position : | chr7:34815932-34817932   |
| Biosample name: | |
| Experiment class : | High+Lowthroughput |
| Enhancer type: | Enhancer |
| Disease: | Myelodysplastic disease |
| Pubmed ID: | 29343483 |
| Enhancer experiment: | RT-qPCR |
| Enhancer experiment description: | Mechanistically, we demonstrate that NR4A1/3 restrict HSC proliferation in part through activation of a C/EBP?-driven anti-proliferative network by directly binding to a hematopoietic-specific Cebpa enhancer and activating Cebpa transcription. |
About Target gene
| Target gene : | Cebpa(C/ebpalpha,CBF-A,Cebp) |
| Strong evidence: | qRT-PCR,qPCR,ChIP,3C |
| Less strong evidence: | RNA-Seq |
| Target gene experiment description: | Mechanistically, we demonstrate that NR4A1/3 restrict HSC proliferation in part through activation of a C/EBP?-driven anti-proliferative network by directly binding to a hematopoietic-specific Cebpa enhancer and activating Cebpa transcription. |
About TF
| TF name : | -- |
| TF experiment: | RT-qPCR |
| TF experiment description: | Mechanistically, we demonstrate that NR4A1/3 restrict HSC proliferation in part through activation of a C/EBP?-driven anti-proliferative network by directly binding to a hematopoietic-specific Cebpa enhancer and activating Cebpa transcription. |
About Function
| Enhancer function : | Mechanistically, we demonstrate that NR4A1/3 restrict HSC proliferation in part through activation of a C/EBP?-driven anti-proliferative network by directly binding to a hematopoietic-specific Cebpa enhancer and activating Cebpa transcription. |
| Enhancer function experiment: | Immunohistochemical staining |
| Enhancer function experiment description: |
Mechanistically, we demonstrate that NR4A1/3 restrict HSC proliferation in part through activation of a C/EBP?-driven anti-proliferative network by directly binding to a hematopoietic-specific Cebpa enhancer and activating Cebpa transcription. |
About SNP
| SNP ID: | -- |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene