About Enhancer
| Enhancer ID: | E_02980 |
| Species: | Mus musculus |
| Position : | chr2:91067374-91069374   |
| Year: | 2014 |
| Title: | The Runx-PU.1 pathway preserves normal and AML/ETO9a leukemic stem cells. |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | Leukemia |
| PMID: | 25185713 |
| Tissue: | blood / hematopoietic system |
| Tissue Ontology ID: | UBERON:0000178 |
| Cell Source: | Bone Marrow Cell,Leukemic Stem Cell,Hematopoietic Stem Cell,416B |
| Experiment Type: | TF-binding/chromatin assay; Chromatin interaction assay; In vivo functional validation; Disease-associated enhancer analysis |
| Low Throughput Method: | ChIP-qPCR/ChIP; 3C; Transgenic/LacZ assay |
About Target Gene
| Target gene : | Spi1 |
About TF
| TF name : | Runx3 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Runx3 | Regulation of nuclear SMAD2/3 signaling | pid | 82 |
| Runx3 | TGF_beta_Receptor | netpath | 220 |
| Runx3 | Hs_TYROBP_Causal_Network_WP3945_90843 | wikipathways | 54 |
| Runx3 | Hs_Sudden_Infant_Death_Syndrome_(SIDS)_Susceptibility_Pathways_WP706_86078 | wikipathways | 33 |
Enhancer Associated Network
Expression of Target Genes for the Enhancer