About Enhancer
| Enhancer ID: | E_02963 |
| Species: | Mus musculus |
| Position : | chr8:18742000-18744000   |
| Year: | 2018 |
| Title: | Arid1a regulates response to anti-angiogenic therapy in advanced hepatocellular carcinoma. |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | hepatocellular carcinoma |
| PMID: | 29113912 |
| MONDO: | MONDO:0007256 |
| Tissue: | liver |
| Tissue Ontology ID: | UBERON:0002107 |
| Cell Source: | ARID1A-deficient mouse hepatocellular carcinoma cells |
| Cell Type: | hepatocyte |
| Cell Ontology ID: | CL:0000182 |
| Experiment Type: | Enhancer chromatin-state assay; chromatin-remodeler occupancy assay; functional perturbation assay; Endogenous enhancer perturbation; TF binding assay; In vivo functional validation |
| Low Throughput Method: | H3K27ac ChIP; ARID1A ChIP; Arid1a shRNA knockdown; conditional Arid1a knockout; qRT-PCR; ELISA; Western blot; xenograft assay; DEN-induced HCC model; anti-ANGPT2 treatment; sorafenib treatment; ChIP; RT-qPCR; shRNA knockdown; Mouse genetic deletion/knock-in; In vivo phenotyping; Xenograft/xenotransplant |
About Target Gene
| Target gene : | Angpt2 |
About TF
| TF name : | Arid1a |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Arid1a | RMTs methylate histone arginines | reactome | 75 |
| Arid1a | Wnt signaling pathway | panther | 250 |
Enhancer Associated Network
Overlapping Enhancers (mm10)
No overlapping enhancers found in mm10 at this locus.
Expression of Target Genes for the Enhancer