About Enhancer
| Enhancer ID: | E_02931 |
| Species: | Mus musculus |
| Position : | chr10:118172284-118172884   |
| Year: | 2019 |
| Title: | Runx1 and ROR污t Cooperate to Upregulate IL-22 Expression in Th Cells through Its Distal Enhancer. |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 31028121 |
| Tissue: | blood |
| Tissue Ontology ID: | UBERON:0000178 |
| Cell Source: | primary naive CD4+ T cells differentiated to Th22 cells |
| Cell Type: | CD4-positive helper T cell |
| Cell Ontology ID: | CL:0000492 |
| Experiment Type: | Enhancer activity assay; TF-binding assay; differentiation-associated enhancer assay; Endogenous enhancer perturbation; TF binding assay |
| Low Throughput Method: | CNS-32 reporter; ROR污t-site mutagenesis; ROR污t ChIP; histone H4 acetylation ChIP; co-expression analysis; Site-directed/motif mutagenesis; Reporter assay |
About Target Gene
| Target gene : | Il22 |
About TF
| TF name : | Rorc |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Rorc | Nuclear Receptor transcription pathway | reactome | 51 |
Enhancer Associated Network
Overlapping Enhancers (mm10)
No overlapping enhancers found in mm10 at this locus.
Expression of Target Genes for the Enhancer