About Enhancer
| Enhancer ID: | E_02832 |
| Species: | Mus musculus |
| Position : | chr7:143462624-143463585   |
| Year: | 2018 |
| Title: | Coordinated d-cyclin/Foxd1 activation drives mitogenic activity of the Sonic Hedgehog signaling pathway. |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 29284139 |
| Cell Source: | Mouse Embryonic Fibroblasts |
| Cell Type: | fibroblast |
| Cell Ontology ID: | CL:0000057 |
| Experiment Type: | Enhancer activity assay; Endogenous enhancer perturbation |
| Low Throughput Method: | Luciferase reporter assay; Reporter assay; CRISPR-Cas9 targeted editing/deletion |
About Target Gene
| Target gene : | Cdkn1c |
About TF
| TF name : | Gli1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Gli1 | Ci/Gli processing signaling ( Hedgehog signaling pathway ) | inoh | 17 |
| Gli1 | Degradation of GLI1 by the proteasome | reactome | 59 |
| Gli1 | FAS signaling pathway | panther | 37 |
| Gli1 | GLI proteins bind promoters of Hh responsive genes to promote transcription | reactome | 7 |
| Gli1 | Hedgehog 'off' state | reactome | 43 |
| Gli1 | Hedgehog 'on' state | reactome | 72 |
| Gli1 | Hedgehog | netpath | 39 |
| Gli1 | Hedgehog signaling events mediated by Gli proteins | pid | 49 |
| Gli1 | Hedgehog signaling pathway | panther | 19 |
| Gli1 | Signaling without Hh ( Hedgehog signaling pathway ) | inoh | 7 |
| Gli1 | Hedgehog signaling pathway | kegg | 53 |
| Gli1 | Pathways in cancer | kegg | 321 |
| Gli1 | Basal cell carcinoma | kegg | 51 |
| Gli1 | Hs_Dopaminergic_Neurogenesis_WP2855_87239 | wikipathways | 19 |
Enhancer Associated Network
Overlapping Enhancers (mm10)
No overlapping enhancers found in mm10 at this locus.
Expression of Target Genes for the Enhancer