About Enhancer
| Enhancer ID: | E_02799 |
| Species: | Mus musculus |
| Position : | chr7:143459000-143459700   |
| Year: | 2018 |
| Title: | Coordinated d-cyclin/Foxd1 activation drives mitogenic activity of the Sonic Hedgehog signaling pathway. |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 29284139 |
| Tissue: | embryonic mesenchyme / fibroblast model |
| Cell Source: | O9-1 cranial neural crest cells |
| Cell Type: | embryonic fibroblast / cranial neural crest-derived cell |
| Cell Ontology ID: | CL:2000042 |
| Experiment Type: | FOXD1-responsive Cdkn1c intronic reporter element; candidate enhancer evidence only (no endogenous enhancer deletion in this paper) |
| High Throughput Method: | Not used for direct enhancer proof in this study |
| Low Throughput Method: | Cdkn1c enh1 luciferase reporter; FOXD1 overexpression; Foxd1 gene CRISPR-Cas9 knockout; SHH stimulation; vismodegib inhibition; RT-qPCR; proliferation assay |
About Target Gene
| Target gene : | Cdkn1c |
About TF
| TF name : | Foxd1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Overlapping Enhancers (mm10)
6 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_02738 | chr7:143459000-143459700 | embryonic mesenchyme / fibroblast model | embryonic fibroblast / cranial neural crest-derived cell | NA |
| E_02794 | chr7:143459000-143459700 | embryo | embryonic fibroblast | NA |
| E_02819 | chr7:143459000-143460200 | embryonic craniofacial mesenchyme | embryonic fibroblast | NA |
| E_02924 | chr7:143459000-143459700 | facial mesenchyme | cranial neural crest cell | NA |
| E_04987 | chr7:143459000-143459700 | embryo | cranial neural crest-derived mesenchymal cell | NA |
| E_02831 | chr7:143459172-143459787 | NA | fibroblast | NA |
Expression of Target Genes for the Enhancer