About Enhancer
| Enhancer ID: | E_02743 |
| Species: | Mus musculus |
| Position : | chr8:84177152-84178151   |
| Year: | 2016 |
| Title: | Foxd3 Promotes Exit from Naive Pluripotency through Enhancer Decommissioning and Inhibits Germline Specification. |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 26748758 |
| Tissue: | embryo |
| Tissue Ontology ID: | UBERON:0000922 |
| Cell Source: | tetON Foxd3 mouse embryonic stem cells |
| Cell Type: | embryonic stem cell |
| Cell Ontology ID: | CL:0002322 |
| Experiment Type: | Enhancer activity assay; TF binding assay; Enhancer decommissioning assay; Functional perturbation assay |
| High Throughput Method: | FOXD3 ChIP-seq; RNA-seq |
| Low Throughput Method: | Stable Nanos3(-1.1) GFP enhancer reporter assay; Doxycycline-induced Foxd3 expression; Enhancer RNA RT-qPCR; H3K27ac ChIP-qPCR; H3K4me2 ChIP-qPCR; H3K27me2 ChIP-qPCR; Foxd3 conditional knockout |
About Target Gene
| Target gene : | Nanos3 |
About TF
| TF name : | Foxd3 |
About Regulatory State
| Regulatory State : | Repressed |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Foxd3 | POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation | reactome | 13 |
| Foxd3 | Hs_Neural_Crest_Differentiation_WP2064_79263 | wikipathways | 40 |
Enhancer Associated Network
Overlapping Enhancers (mm10)
No overlapping enhancers found in mm10 at this locus.
Expression of Target Genes for the Enhancer