About Enhancer
| Enhancer ID: | E_02723 |
| Species: | Mus musculus |
| Position : | chr11:44390082-44390626   |
| Year: | 2011 |
| Title: | A distal enhancer in Il12b is the target of transcriptional repression by the STAT3 pathway and requires the basic leucine zipper (B-ZIP) protein NFIL3. |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 21566115 |
| Tissue: | bone marrow |
| Tissue Ontology ID: | UBERON:0002371 |
| Cell Source: | Primary bone marrow-derived macrophages |
| Cell Type: | macrophage |
| Cell Ontology ID: | CL:0000235 |
| Experiment Type: | Enhancer activity assay; TF binding assay; Functional perturbation assay |
| Low Throughput Method: | Luciferase reporter assay; enhancer deletion and site-directed mutagenesis; NFIL3 ChIP-qPCR; Nfil3 knockout; RT-qPCR; cytokine measurement |
About Target Gene
| Target gene : | Il12b |
About TF
| TF name : | Nfil3 |
About Regulatory State
| Regulatory State : | Repressed |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Overlapping Enhancers (mm10)
7 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_05348 | chr11:44386118-44393090 | NA | macrophage | Inflammatory Disease |
| E_02929 | chr11:44389500-44390500 | blood | macrophage | NA |
| E_05235 | chr11:44390063-44390123 | NA | NA | NA |
| E_02793 | chr11:44390069-44390173 | ascitic fluid | macrophage | NA |
| E_02833 | chr11:44390069-44390173 | bone marrow | macrophage | NA |
| E_02874 | chr11:44390069-44390173 | peritoneal cavity | macrophage | NA |
| E_02915 | chr11:44390342-44392251 | blood / hematopoietic system | T cell | Autoimmune and Inflammatory Diseases |
Expression of Target Genes for the Enhancer