Enhancer Detail

Comprehensive information about experimentally validated enhancers

About Enhancer
Enhancer ID: E_02701
Species: Mus musculus
Position : chr14:55525638-55525920
Year: 2011
Title: Combinatorial regulation of photoreceptor differentiation factor, neural retina leucine zipper gene NRL, revealed by in vivo promoter analysis.
Genome Build: mm10
Enhancer Type: Enhancer
Condition: Normal
PMID:  21673114
Tissue: retina
Tissue Ontology ID: UBERON:0000966
Cell Source: mouse retina in vivo
Cell Type: rod photoreceptor
Experiment Type: In vivo enhancer/promoter dissection; TF binding
Low Throughput Method: Neonatal-retina reporter electroporation; EMSA/supershift; RORE mutation at -783/-771 abolishing reporter expression
About Target Gene
Target gene : Nrl
About TF
TF name : Rorb
About Regulatory State
Regulatory State : Active
Upstream Pathway Annotation of TF
GeneName Pathway Name Source Gene Number
Rorb Nuclear Receptor transcription pathway reactome 51
Enhancer Associated Network
Overlapping Enhancers (mm10) 6 found
Enhancer ID Position Tissue Cell Disease
E_02647 chr14:55525638-55525795 retina retinal rod cell NA
E_02658 chr14:55525638-55525795 retina retinal rod cell NA
E_02659 chr14:55525638-55525795 retina retinal rod cell NA
E_02660 chr14:55525638-55525795 retina retinal rod cell NA
E_02685 chr14:55525638-55525920 retina rod photoreceptor NA
E_02686 chr14:55525638-55525920 retina rod photoreceptor NA
Expression of Target Genes for the Enhancer