About Enhancer
| Enhancer ID: | E_02588 |
| Species: | Mus musculus |
| Position : | chr6:127033997-127036097   |
| Year: | 2018 |
| Title: | A Novel Distal Enhancer Mediates Inflammation-, PTH-, and Early Onset Murine Kidney Disease-Induced Expression of the Mouse Fgf23 Gene. |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | chronic kidney disease |
| PMID: | 29527594 |
| MONDO: | MONDO:0005300 |
| Tissue: | kidney |
| Tissue Ontology ID: | UBERON:0002113 |
| Cell Source: | Osteocyte Cell Lines |
| Experiment Type: | TF-binding/chromatin assay; Endogenous enhancer perturbation; Disease-associated enhancer analysis |
| High Throughput Method: | ChIP-seq |
| Low Throughput Method: | CRISPR-Cas9 targeted editing/deletion; ChIP-qPCR/ChIP |
About Target Gene
| Target gene : | Fgf23 |
About TF
| TF name : | Hif1a |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Hif1a | Angiogenesis | panther | 141 |
| Hif1a | AP-1 transcription factor network | pid | 71 |
| Hif1a | BMAL1:CLOCK,NPAS2 activates circadian gene expression | reactome | 42 |
| Hif1a | Circadian Clock | reactome | 49 |
| Hif1a | HIF-1-alpha transcription factor network | pid | 67 |
| Hif1a | Hypoxia response via HIF activation | panther | 16 |
| Hif1a | Hypoxic and oxygen homeostasis regulation of HIF-1-alpha | pid | 19 |
| Hif1a | Notch-mediated HES/HEY network | pid | 48 |
| Hif1a | NOTCH1 Intracellular Domain Regulates Transcription | reactome | 47 |
| Hif1a | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | reactome | 18 |
| Hif1a | Parkinson disease | panther | 85 |
| Hif1a | PTK6 Expression | reactome | 5 |
| Hif1a | PTK6 promotes HIF1A stabilization | reactome | 6 |
| Hif1a | Regulation of gene expression by Hypoxia-inducible Factor | reactome | 10 |
| Hif1a | VEGF signaling pathway | panther | 54 |
| Hif1a | VEGFR1 specific signals | pid | 29 |
| Hif1a | mTOR signaling pathway | kegg | 50 |
| Hif1a | Pathways in cancer | kegg | 321 |
| Hif1a | Renal cell carcinoma | kegg | 65 |
| Hif1a | Hs_Hepatitis_C_and_Hepatocellular_Carcinoma_WP3646_88640 | wikipathways | 36 |
| Hif1a | Hs_Focal_Adhesion-PI3K-Akt-mTOR-signaling_pathway_WP3932_91101 | wikipathways | 8 |
| Hif1a | Hs_AGE-RAGE_pathway_WP2324_89798 | wikipathways | 27 |
| Hif1a | Hs_Notch_Signaling_Pathway_WP61_78592 | wikipathways | 16 |
Enhancer Associated Network
Overlapping Enhancers (mm10)
1 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_02589 | chr6:127033997-127036097 | kidney | NA | chronic kidney disease |
Expression of Target Genes for the Enhancer