About Enhancer
| Enhancer ID: | E_02582 |
| Species: | Mus musculus |
| Position : | chr6:127006796-127007720   |
| Year: | 2018 |
| Title: | A Novel Distal Enhancer Mediates Inflammation-, PTH-, and Early Onset Murine Kidney Disease-Induced Expression of the Mouse Fgf23 Gene. |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | chronic kidney disease |
| PMID: | 29527594 |
| MONDO: | MONDO:0005300 |
| Tissue: | kidney |
| Tissue Ontology ID: | UBERON:0002113 |
| Cell Source: | Bone marrow-derived mesenchymal stem cells |
| Cell Type: | mesenchymal stromal cell |
| Cell Ontology ID: | CL:0000499 |
| Experiment Type: | Functional genomics assay, Epigenomic profiling assay, Genome editing assay, Transcriptional regulation assay, In vivo functional assay |
| High Throughput Method: | ChIP-seq; Microarray; Comparative genomic conservation analysis |
| Low Throughput Method: | CRISPR-Cas9 enhancer deletion; RT-RT-qPCR; FGF23 ELISA; DXA; Serum biochemical analysis; Genotyping PCR; Sanger sequencing; In vivo LPS stimulation assay; In vivo cytokine stimulation assay; In vivo PTH stimulation assay; In vivo CKD model assay; CRISPR-Cas9 |
About Target Gene
| Target gene : | Fgf23 |
About TF
| TF name : | Stat6 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Stat6 | Downstream signal transduction | reactome | 29 |
| Stat6 | EGF receptor signaling pathway | panther | 109 |
| Stat6 | Gene expression of SOCS by STAT dimer ( JAK-STAT pathway and regulation pathway Diagram ) | inoh | 14 |
| Stat6 | Gene expression of SOCS1 by STAT dimer ( JAK-STAT pathway and regulation pathway Diagram ) | inoh | 8 |
| Stat6 | Gene expression of SOCS3 by STAT dimer ( JAK-STAT pathway and regulation pathway Diagram ) | inoh | 8 |
| Stat6 | IL-13 signaling pathway(JAK1 TYK2 STAT6) ( IL-13 signaling(JAK1 TYK2 STAT6) ) | inoh | 10 |
| Stat6 | IL-4 signaling pathway(JAK1 JAK3 STAT6) ( IL-4 signaling(JAK1 JAK3 STAT6) ) | inoh | 7 |
| Stat6 | IL12-mediated signaling events | pid | 62 |
| Stat6 | IL4-mediated signaling events | pid | 66 |
| Stat6 | IL4 | netpath | 75 |
| Stat6 | IL9 | netpath | 24 |
| Stat6 | Interleukin signaling pathway | panther | 86 |
| Stat6 | JAK-STAT pathway and regulation pathway ( JAK-STAT pathway and regulation pathway Diagram ) | inoh | 97 |
| Stat6 | JAK/STAT signaling pathway | panther | 15 |
| Stat6 | PDGF signaling pathway | panther | 113 |
| Stat6 | Positive regulation of (Transcription of SOCS by STAT dimer) in JAK STAT pathway ( JAK-STAT pathway and regulation pathway Diagram ) | inoh | 178 |
| Stat6 | Signaling events mediated by TCPTP | pid | 40 |
| Stat6 | TSLP | netpath | 24 |
| Stat6 | Jak-STAT signaling pathway | kegg | 149 |
| Stat6 | Hs_Tryptophan_metabolism_WP465_85055 | wikipathways | 45 |
| Stat6 | Hs_Cytokines_and_Inflammatory_Response_WP530_79331 | wikipathways | 21 |
| Stat6 | Hs_TGF-beta_Receptor_Signaling_WP560_90187 | wikipathways | 28 |
| Stat6 | Hs_G1_to_S_cell_cycle_control_WP45_80001 | wikipathways | 8 |
| Stat6 | Hs_IL-4_Signaling_Pathway_WP395_89828 | wikipathways | 41 |
Enhancer Associated Network
Overlapping Enhancers (mm10)
10 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_02564 | chr6:127006796-127007720 | bone | osteocyte | chronic kidney disease |
| E_02574 | chr6:127006796-127007720 | kidney | mesenchymal stromal cell | chronic kidney disease |
| E_02575 | chr6:127006796-127007720 | kidney | mesenchymal stromal cell | chronic kidney disease |
| E_02576 | chr6:127006796-127007720 | kidney | mesenchymal stromal cell | chronic kidney disease |
| E_02577 | chr6:127006796-127007720 | kidney | mesenchymal stromal cell | chronic kidney disease |
| E_02578 | chr6:127006796-127007720 | kidney | mesenchymal stromal cell | chronic kidney disease |
| E_02579 | chr6:127006796-127007720 | kidney | mesenchymal stromal cell | chronic kidney disease |
| E_02580 | chr6:127006796-127007720 | kidney | mesenchymal stromal cell | chronic kidney disease |
| E_02581 | chr6:127006796-127007720 | kidney | mesenchymal stromal cell | chronic kidney disease |
| E_02585 | chr6:127006796-127007720 | bone | osteocyte | chronic kidney disease |
Expression of Target Genes for the Enhancer