About Enhancer
| Enhancer ID: | E_02577 |
| Species: | Mus musculus |
| Position : | chr6:127006796-127007720   |
| Year: | 2018 |
| Title: | A Novel Distal Enhancer Mediates Inflammation-, PTH-, and Early Onset Murine Kidney Disease-Induced Expression of the Mouse Fgf23 Gene. |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | chronic kidney disease |
| PMID: | 29527594 |
| MONDO: | MONDO:0005300 |
| Tissue: | kidney |
| Tissue Ontology ID: | UBERON:0002113 |
| Cell Source: | Bone marrow-derived mesenchymal stem cells |
| Cell Type: | mesenchymal stromal cell |
| Cell Ontology ID: | CL:0000499 |
| Experiment Type: | Functional genomics assay, Epigenomic profiling assay, Genome editing assay, Transcriptional regulation assay, In vivo functional assay |
| High Throughput Method: | ChIP-seq; Microarray; Comparative genomic conservation analysis |
| Low Throughput Method: | CRISPR-Cas9 enhancer deletion; RT-RT-qPCR; FGF23 ELISA; DXA; Serum biochemical analysis; Genotyping PCR; Sanger sequencing; In vivo LPS stimulation assay; In vivo cytokine stimulation assay; In vivo PTH stimulation assay; In vivo CKD model assay; CRISPR-Cas9 |
About Target Gene
| Target gene : | Fgf23 |
About TF
| TF name : | Hif1a |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Hif1a | Angiogenesis | panther | 141 |
| Hif1a | AP-1 transcription factor network | pid | 71 |
| Hif1a | BMAL1:CLOCK,NPAS2 activates circadian gene expression | reactome | 42 |
| Hif1a | Circadian Clock | reactome | 49 |
| Hif1a | HIF-1-alpha transcription factor network | pid | 67 |
| Hif1a | Hypoxia response via HIF activation | panther | 16 |
| Hif1a | Hypoxic and oxygen homeostasis regulation of HIF-1-alpha | pid | 19 |
| Hif1a | Notch-mediated HES/HEY network | pid | 48 |
| Hif1a | NOTCH1 Intracellular Domain Regulates Transcription | reactome | 47 |
| Hif1a | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | reactome | 18 |
| Hif1a | Parkinson disease | panther | 85 |
| Hif1a | PTK6 Expression | reactome | 5 |
| Hif1a | PTK6 promotes HIF1A stabilization | reactome | 6 |
| Hif1a | Regulation of gene expression by Hypoxia-inducible Factor | reactome | 10 |
| Hif1a | VEGF signaling pathway | panther | 54 |
| Hif1a | VEGFR1 specific signals | pid | 29 |
| Hif1a | mTOR signaling pathway | kegg | 50 |
| Hif1a | Pathways in cancer | kegg | 321 |
| Hif1a | Renal cell carcinoma | kegg | 65 |
| Hif1a | Hs_Hepatitis_C_and_Hepatocellular_Carcinoma_WP3646_88640 | wikipathways | 36 |
| Hif1a | Hs_Focal_Adhesion-PI3K-Akt-mTOR-signaling_pathway_WP3932_91101 | wikipathways | 8 |
| Hif1a | Hs_AGE-RAGE_pathway_WP2324_89798 | wikipathways | 27 |
| Hif1a | Hs_Notch_Signaling_Pathway_WP61_78592 | wikipathways | 16 |
Enhancer Associated Network
Overlapping Enhancers (mm10)
10 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_02564 | chr6:127006796-127007720 | bone | osteocyte | chronic kidney disease |
| E_02574 | chr6:127006796-127007720 | kidney | mesenchymal stromal cell | chronic kidney disease |
| E_02575 | chr6:127006796-127007720 | kidney | mesenchymal stromal cell | chronic kidney disease |
| E_02576 | chr6:127006796-127007720 | kidney | mesenchymal stromal cell | chronic kidney disease |
| E_02578 | chr6:127006796-127007720 | kidney | mesenchymal stromal cell | chronic kidney disease |
| E_02579 | chr6:127006796-127007720 | kidney | mesenchymal stromal cell | chronic kidney disease |
| E_02580 | chr6:127006796-127007720 | kidney | mesenchymal stromal cell | chronic kidney disease |
| E_02581 | chr6:127006796-127007720 | kidney | mesenchymal stromal cell | chronic kidney disease |
| E_02582 | chr6:127006796-127007720 | kidney | mesenchymal stromal cell | chronic kidney disease |
| E_02585 | chr6:127006796-127007720 | bone | osteocyte | chronic kidney disease |
Expression of Target Genes for the Enhancer