About Enhancer
| Enhancer ID: | E_02575 |
| Species: | Mus musculus |
| Position : | chr6:127006796-127007720   |
| Year: | 2018 |
| Title: | A Novel Distal Enhancer Mediates Inflammation-, PTH-, and Early Onset Murine Kidney Disease-Induced Expression of the Mouse Fgf23 Gene. |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | chronic kidney disease |
| PMID: | 29527594 |
| MONDO: | MONDO:0005300 |
| Tissue: | kidney |
| Tissue Ontology ID: | UBERON:0002113 |
| Cell Source: | Bone marrow-derived mesenchymal stem cells |
| Cell Type: | mesenchymal stromal cell |
| Cell Ontology ID: | CL:0000499 |
| Experiment Type: | Functional genomics assay, Epigenomic profiling assay, Genome editing assay, Transcriptional regulation assay, In vivo functional assay |
| High Throughput Method: | ChIP-seq; Microarray; Comparative genomic conservation analysis |
| Low Throughput Method: | CRISPR-Cas9 enhancer deletion; RT-RT-qPCR; FGF23 ELISA; DXA; Serum biochemical analysis; Genotyping PCR; Sanger sequencing; In vivo LPS stimulation assay; In vivo cytokine stimulation assay; In vivo PTH stimulation assay; In vivo CKD model assay; CRISPR-Cas9 |
About Target Gene
| Target gene : | Fgf23 |
About TF
| TF name : | Arntl |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Arntl | BMAL1:CLOCK,NPAS2 activates circadian gene expression | reactome | 42 |
| Arntl | Circadian Clock | reactome | 49 |
| Arntl | Circadian clock system | panther | 9 |
| Arntl | Circadian rhythm pathway | pid | 17 |
| Arntl | NR1D1 (REV-ERBA) represses gene expression | reactome | 8 |
| Arntl | PPARA activates gene expression | reactome | 113 |
| Arntl | RORA activates gene expression | reactome | 27 |
| Arntl | Circadian rhythm - mammal | kegg | 19 |
| Arntl | Circadian rhythm - fly | kegg | 7 |
| Arntl | Hs_Selenium_Metabolism_and_Selenoproteins_WP28_71888 | wikipathways | 9 |
| Arntl | Hs_Hedgehog_Signaling_Pathway_WP47_78542 | wikipathways | 6 |
Enhancer Associated Network
Overlapping Enhancers (mm10)
10 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_02564 | chr6:127006796-127007720 | bone | osteocyte | chronic kidney disease |
| E_02574 | chr6:127006796-127007720 | kidney | mesenchymal stromal cell | chronic kidney disease |
| E_02576 | chr6:127006796-127007720 | kidney | mesenchymal stromal cell | chronic kidney disease |
| E_02577 | chr6:127006796-127007720 | kidney | mesenchymal stromal cell | chronic kidney disease |
| E_02578 | chr6:127006796-127007720 | kidney | mesenchymal stromal cell | chronic kidney disease |
| E_02579 | chr6:127006796-127007720 | kidney | mesenchymal stromal cell | chronic kidney disease |
| E_02580 | chr6:127006796-127007720 | kidney | mesenchymal stromal cell | chronic kidney disease |
| E_02581 | chr6:127006796-127007720 | kidney | mesenchymal stromal cell | chronic kidney disease |
| E_02582 | chr6:127006796-127007720 | kidney | mesenchymal stromal cell | chronic kidney disease |
| E_02585 | chr6:127006796-127007720 | bone | osteocyte | chronic kidney disease |
Expression of Target Genes for the Enhancer