About Enhancer
| Enhancer ID: | E_02565 |
| Species: | Mus musculus |
| Position : | chr9:99032500-99033051   |
| Year: | 2015 |
| Title: | Pi3kcb links Hippo-YAP and PI3K-AKT signaling pathways to promote cardiomyocyte proliferation and survival. |
| Genome Build: | mm9 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 25249570 |
| Tissue: | heart |
| Tissue Ontology ID: | UBERON:0000948 |
| Cell Source: | neonatal rat ventricular cardiomyocytes |
| Cell Type: | cardiac muscle cell |
| Cell Ontology ID: | CL:0000746 |
| Experiment Type: | Enhancer activity assay; Functional perturbation assay; TF binding assay |
| Low Throughput Method: | 552-bp luciferase reporter assay; TEAD-site mutagenesis; YAP overexpression; YAP[S94A] mutant assay; qRT-PCR; siRNA/shRNA perturbation; ChIP |
About Target Gene
| Target gene : | Pik3cb |
About TF
| TF name : | Tead1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Tead1 | PPARA activates gene expression | reactome | 113 |
| Tead1 | YAP1- and WWTR1 (TAZ)-stimulated gene expression | reactome | 29 |
| Tead1 | Hs_Mesodermal_Commitment_Pathway_WP2857_87780 | wikipathways | 47 |
Enhancer Associated Network
Overlapping Enhancers (mm9)
No overlapping enhancers found in mm9 at this locus.
Expression of Target Genes for the Enhancer