About Enhancer
| Enhancer ID: | E_02516 |
| Species: | Mus musculus |
| Position : | chr6:128542796-128543720   |
| Year: | 2018 |
| Title: | A Novel Distal Enhancer Mediates Inflammation-, PTH-, and Early Onset Murine Kidney Disease-Induced Expression of the Mouse Fgf23 Gene. |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | chronic kidney disease |
| PMID: | 29527594 |
| MONDO: | MONDO:0005300 |
| Tissue: | kidney |
| Tissue Ontology ID: | UBERON:0002113 |
| Cell Source: | Conventional dendritic cells |
| Cell Type: | conventional dendritic cell |
| Cell Ontology ID: | CL:0000990 |
| Experiment Type: | Functional genomics assay, Epigenomic profiling assay, Genome editing assay, In vivo functional assay; Endogenous enhancer perturbation; TF binding assay; Chromatin-state profiling; In vivo functional validation |
| High Throughput Method: | ChIP-seq, Microarray; ChIP-seq |
| Low Throughput Method: | CRISPR-Cas9 enhancer deletion, RT-RT-qPCR, FGF23 ELISA, Serum biochemical analysis, In vivo LPS stimulation assay, In vivo CKD model assay; CRISPR-Cas9 endogenous deletion/editing; ChIP; Mouse genetic deletion/knock-in |
About Target Gene
| Target gene : | Fgf23 |
About TF
| TF name : | Arntl |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Arntl | BMAL1:CLOCK,NPAS2 activates circadian gene expression | reactome | 42 |
| Arntl | Circadian Clock | reactome | 49 |
| Arntl | Circadian clock system | panther | 9 |
| Arntl | Circadian rhythm pathway | pid | 17 |
| Arntl | NR1D1 (REV-ERBA) represses gene expression | reactome | 8 |
| Arntl | PPARA activates gene expression | reactome | 113 |
| Arntl | RORA activates gene expression | reactome | 27 |
| Arntl | Circadian rhythm - mammal | kegg | 19 |
| Arntl | Circadian rhythm - fly | kegg | 7 |
| Arntl | Hs_Selenium_Metabolism_and_Selenoproteins_WP28_71888 | wikipathways | 9 |
| Arntl | Hs_Hedgehog_Signaling_Pathway_WP47_78542 | wikipathways | 6 |
Enhancer Associated Network
Overlapping Enhancers (mm10)
8 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_02515 | chr6:128542796-128543720 | kidney | conventional dendritic cell | chronic kidney disease |
| E_02517 | chr6:128542796-128543720 | kidney | conventional dendritic cell | chronic kidney disease |
| E_02518 | chr6:128542796-128543720 | kidney | conventional dendritic cell | chronic kidney disease |
| E_02519 | chr6:128542796-128543720 | kidney | conventional dendritic cell | chronic kidney disease |
| E_02520 | chr6:128542796-128543720 | kidney | conventional dendritic cell | chronic kidney disease |
| E_02521 | chr6:128542796-128543720 | kidney | conventional dendritic cell | chronic kidney disease |
| E_02522 | chr6:128542796-128543720 | kidney | conventional dendritic cell | chronic kidney disease |
| E_02523 | chr6:128542796-128543720 | kidney | conventional dendritic cell | chronic kidney disease |
Expression of Target Genes for the Enhancer