About Enhancer
| Enhancer ID: | E_02493 |
| Species: | Mus musculus |
| Position : | chr3:94384282-94384650   |
| Year: | 2026 |
| Title: | ROR污t+ APCs require a distinct cis-regulatory element to instruct tolerance to dietary antigens |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 41723158 |
| Tissue: | small intestine |
| Tissue Ontology ID: | UBERON:0002108 |
| Cell Source: | MNK-3 ILC3-like cells for mechanistic assays |
| Cell Type: | group 3 innate lymphoid cell / ROR污t+ antigen-presenting cell |
| Cell Ontology ID: | CL:0001071 |
| Experiment Type: | OCR369 endogenous enhancer deletion; RUNX3 binding; enhancer-promoter looping; intestinal immune-homeostasis phenotyping |
| High Throughput Method: | ATAC-seq reanalysis; scRNA-seq; RNA-seq; DNA-pulldown mass spectrometry |
| Low Throughput Method: | 369-bp endogenous OCR369 deletion; RUNX3 CUT&RUN-qPCR; 3C-qPCR; RT-qPCR; dual-luciferase reporter; flow cytometry; bone-marrow chimera; oral-tolerance/allergy phenotyping |
About Target Gene
| Target gene : | Rorc |
About TF
| TF name : | Runx3 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Runx3 | Regulation of nuclear SMAD2/3 signaling | pid | 82 |
| Runx3 | TGF_beta_Receptor | netpath | 220 |
| Runx3 | Hs_TYROBP_Causal_Network_WP3945_90843 | wikipathways | 54 |
| Runx3 | Hs_Sudden_Infant_Death_Syndrome_(SIDS)_Susceptibility_Pathways_WP706_86078 | wikipathways | 33 |
Enhancer Associated Network
Overlapping Enhancers (mm10)
1 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_02462 | chr3:94384282-94384650 | small intestine | group 3 innate lymphoid cell / ROR污t+ antigen-presenting cell | NA |
Expression of Target Genes for the Enhancer