About Enhancer
| Enhancer ID: | E_02473 |
| Species: | Mus musculus |
| Position : | chr9:71241739-71242765   |
| Year: | 2021 |
| Title: | Tbx5 drives Aldh1a2 expression to regulate a RA-Hedgehog-Wnt gene regulatory network coordinating cardiopulmonary development. |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 34643182 |
| Tissue: | alimentary part of gastrointestinal system |
| Tissue Ontology ID: | UBERON:0005409 |
| Cell Source: | E14.5 fetal lung |
| Cell Type: | cardiopulmonary progenitor cell |
| Experiment Type: | Enhancer activity assay; TF binding assay; Functional perturbation assay |
| High Throughput Method: | Tbx5 ChIP-seq; ATAC-seq |
| Low Throughput Method: | Luciferase reporter assay; GFP transgenic reporter assay; Tbx5 motif mutation assay; RT-qPCR |
About Target Gene
| Target gene : | Aldh1a2 |
About TF
| TF name : | Tbx5 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Tbx5 | Physiological factors | reactome | 12 |
| Tbx5 | YAP1- and WWTR1 (TAZ)-stimulated gene expression | reactome | 29 |
| Tbx5 | Hs_Heart_Development_WP1591_90186 | wikipathways | 28 |
Enhancer Associated Network
Overlapping Enhancers (mm10)
1 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_02603 | chr9:71241739-71242765 | alimentary part of gastrointestinal system | developing mesodermal progenitor | NA |
Expression of Target Genes for the Enhancer