About Enhancer
| Enhancer ID: | E_02460 |
| Species: | Mus musculus |
| Position : | chr6:88116954-88117210   |
| Year: | 2021 |
| Title: | Gata2 -77 enhancer regulates adult hematopoietic stem cell survival. |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 32594099 |
| Tissue: | spleen |
| Tissue Ontology ID: | UBERON:0002106 |
| Cell Source: | Primary adult mouse splenic HSPCs from WT, Gata2 -77+/-, and Gata2+/- mice |
| Cell Type: | hematopoietic multipotent progenitor cell |
| Cell Ontology ID: | CL:0000837 |
| Experiment Type: | In vivo endogenous enhancer haploinsufficiency analysis; hematopoietic progenitor survival and cell-cycle analysis; hematopoietic compartment phenotyping |
| Low Throughput Method: | Multicolor flow cytometry; Annexin V/DAPI apoptosis assay; Ki67/DAPI cell-cycle assay; qRT-PCR; competitive hematopoietic reconstitution analysis |
About Target Gene
| Target gene : | Gata2 |
About TF
| TF name : | Gata2 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Gata2 | AP-1 transcription factor network | pid | 71 |
| Gata2 | Factors involved in megakaryocyte development and platelet production | reactome | 111 |
| Gata2 | HIF-1-alpha transcription factor network | pid | 67 |
| Gata2 | IL3 | netpath | 84 |
| Gata2 | Regulation of Androgen receptor activity | pid | 54 |
| Gata2 | Signaling events mediated by HDAC Class I | pid | 89 |
| Gata2 | Signaling events mediated by HDAC Class II | pid | 58 |
| Gata2 | Hs_Apoptosis_WP254_88977 | wikipathways | 31 |
Enhancer Associated Network
Overlapping Enhancers (mm10)
No overlapping enhancers found in mm10 at this locus.
Expression of Target Genes for the Enhancer