About Enhancer
| Enhancer ID: | E_02457 |
| Species: | Mus musculus |
| Position : | chr17:44839381-44839469   |
| Year: | 2014 |
| Title: | Dlx5 and mef2 regulate a novel runx2 enhancer for osteoblast-specific expression. |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 24692107 |
| Tissue: | bone element |
| Tissue Ontology ID: | UBERON:0001474 |
| Cell Source: | Primary mouse osteoblasts |
| Cell Type: | osteoblast |
| Cell Ontology ID: | CL:0000062 |
| Experiment Type: | Enhancer activity assay, TF binding assay; Disease-variant functional analysis |
| Low Throughput Method: | Transgenic Reporter Assay, Luciferase Reporter Assay, EMSA, ChIP-RT-qPCR, GST-pulldown |
About Target Gene
| Target gene : | Runx2 |
About TF
| TF name : | Dlx5 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Dlx5 | Validated transcriptional targets of deltaNp63 isoforms | pid | 47 |
| Dlx5 | Hs_MECP2_and_Associated_Rett_Syndrome_WP3584_91190 | wikipathways | 12 |
| Dlx5 | Hs_Neural_Crest_Differentiation_WP2064_79263 | wikipathways | 40 |
Enhancer Associated Network
Expression of Target Genes for the Enhancer