About Enhancer
| Enhancer ID: | E_02437 |
| Species: | Mus musculus |
| Position : | chr9:119469902-119469913   |
| Year: | 2012 |
| Title: | TBX5 drives Scn5a expression to regulate cardiac conduction system function. |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | Cardiac Conduction System Disease |
| PMID: | 22728936 |
| Tissue: | heart |
| Tissue Ontology ID: | UBERON:0000948 |
| Cell Source: | HL-1 |
| Experiment Type: | Enhancer activity assay; TF-binding/chromatin assay; In vivo functional validation; Disease-associated enhancer analysis |
| High Throughput Method: | ChIP-seq |
| Low Throughput Method: | Luciferase reporter assay; Reporter assay; ChIP-qPCR/ChIP |
About Target Gene
| Target gene : | Scn5a |
About TF
| TF name : | Tbx5 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Tbx5 | Physiological factors | reactome | 12 |
| Tbx5 | YAP1- and WWTR1 (TAZ)-stimulated gene expression | reactome | 29 |
| Tbx5 | Hs_Heart_Development_WP1591_90186 | wikipathways | 28 |
Enhancer Associated Network
Overlapping Enhancers (mm10)
No overlapping enhancers found in mm10 at this locus.
Expression of Target Genes for the Enhancer