About Enhancer
| Enhancer ID: | E_02430 |
| Species: | Mus musculus |
| Position : | chr17:44464986-44466986   |
| Year: | 2014 |
| Title: | Dlx5 and mef2 regulate a novel runx2 enhancer for osteoblast-specific expression. |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 24692107 |
| Cell Source: | Osteoblast-Specific Cell |
| Experiment Type: | Enhancer activity assay; TF-binding/chromatin assay; In vivo functional validation |
| Low Throughput Method: | Luciferase reporter assay; Reporter assay; ChIP-qPCR/ChIP; EMSA/gel-shift assay; Transgenic/LacZ assay |
About Target Gene
| Target gene : | Runx2 |
About TF
| TF name : | Mef2c |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Mef2c | CDO in myogenesis | reactome | 29 |
| Mef2c | Circadian Clock | reactome | 49 |
| Mef2c | ErbB1 downstream signaling | pid | 105 |
| Mef2c | ERK/MAPK targets | reactome | 17 |
| Mef2c | Notch | netpath | 76 |
| Mef2c | Oxidative stress response | panther | 23 |
| Mef2c | p38 MAPK pathway | panther | 31 |
| Mef2c | Regulation of nuclear SMAD2/3 signaling | pid | 82 |
| Mef2c | Regulation of retinoblastoma protein | pid | 67 |
| Mef2c | Signaling events mediated by HDAC Class II | pid | 58 |
| Mef2c | Signaling mediated by p38-alpha and p38-beta | pid | 35 |
| Mef2c | TGF_beta_Receptor | netpath | 220 |
| Mef2c | Transcriptional activation of mitochondrial biogenesis | reactome | 43 |
| Mef2c | Trk receptor signaling mediated by the MAPK pathway | pid | 34 |
| Mef2c | MAPK signaling pathway | kegg | 264 |
| Mef2c | Hs_Endochondral_Ossification_WP474_87977 | wikipathways | 43 |
| Mef2c | Hs_VEGFA-VEGFR2_Signaling_Pathway_WP3888_90000 | wikipathways | 153 |
| Mef2c | Hs_Heart_Development_WP1591_90186 | wikipathways | 28 |
| Mef2c | Hs_Oxidation_by_Cytochrome_P450_WP43_84102 | wikipathways | 14 |
| Mef2c | Hs_TGF-beta_Signaling_Pathway_WP366_90028 | wikipathways | 67 |
Enhancer Associated Network
Overlapping Enhancers (mm10)
6 found
Expression of Target Genes for the Enhancer