Enhancer Detail

Comprehensive information about experimentally validated enhancers

About Enhancer
Enhancer ID: E_02429
Species: Mus musculus
Position : chr17:44464986-44466986
Year: 2014
Title: Dlx5 and mef2 regulate a novel runx2 enhancer for osteoblast-specific expression.
Genome Build: mm10
Enhancer Type: Enhancer
Condition: Normal
PMID:  24692107
Cell Source: Osteoblast-Specific Cell
Experiment Type: Enhancer activity assay; TF-binding/chromatin assay; In vivo functional validation
Low Throughput Method: Luciferase reporter assay; Reporter assay; ChIP-qPCR/ChIP; EMSA/gel-shift assay; Transgenic/LacZ assay
About Target Gene
Target gene : Runx2
About TF
TF name : Dlx5
About Regulatory State
Regulatory State : Active
Upstream Pathway Annotation of TF
GeneName Pathway Name Source Gene Number
Dlx5 Validated transcriptional targets of deltaNp63 isoforms pid 47
Dlx5 Hs_MECP2_and_Associated_Rett_Syndrome_WP3584_91190 wikipathways 12
Dlx5 Hs_Neural_Crest_Differentiation_WP2064_79263 wikipathways 40
Enhancer Associated Network
Overlapping Enhancers (mm10) 6 found
Enhancer ID Position Tissue Cell Disease
E_02428 chr17:44464986-44466986 NA NA NA
E_02430 chr17:44464986-44466986 NA NA NA
E_02431 chr17:44464986-44466986 NA NA NA
E_02432 chr17:44464986-44466986 NA NA NA
E_02433 chr17:44464986-44466986 NA NA NA
E_02434 chr17:44464986-44466986 NA NA NA
Expression of Target Genes for the Enhancer