About Enhancer
| Enhancer ID: | E_02409 |
| Species: | Mus musculus |
| Position : | chr9:119378051-119379479   |
| Year: | 2012 |
| Title: | TBX5 drives Scn5a expression to regulate cardiac conduction system function. |
| Genome Build: | mm9 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 22728936 |
| Tissue: | heart |
| Tissue Ontology ID: | UBERON:0000948 |
| Cell Source: | mouse ventricular conduction system |
| Cell Type: | cardiac muscle cell |
| Cell Ontology ID: | CL:0000746 |
| Experiment Type: | In vivo enhancer validation; TF-site functional dissection; Disease-variant functional analysis; In vivo functional validation |
| High Throughput Method: | ChIP-seq / cardiac regulatory profiling; GWAS |
| Low Throughput Method: | Transgenic lacZ reporter; luciferase assay; T-box motif mutagenesis; RT-qPCR; In vivo phenotyping |
About Target Gene
| Target gene : | Scn5a |
About TF
| TF name : | Tbx5 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Tbx5 | Physiological factors | reactome | 12 |
| Tbx5 | YAP1- and WWTR1 (TAZ)-stimulated gene expression | reactome | 29 |
| Tbx5 | Hs_Heart_Development_WP1591_90186 | wikipathways | 28 |
Enhancer Associated Network
Expression of Target Genes for the Enhancer