About Enhancer
| Enhancer ID: | E_02393 |
| Species: | Mus musculus |
| Position : | chr3:94294960-94295960   |
| Year: | 2026 |
| Title: | The conserved noncoding sequence CNS11 is a master control region for Rorc transcription in type 17 immune cells. |
| Genome Build: | mm39 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 41739921 |
| Tissue: | small intestine |
| Tissue Ontology ID: | UBERON:0002108 |
| Cell Source: | primary mouse type 17 immune cells (Th17, ILC3, ROR污t+ Treg, 污汛T and APC populations) |
| Cell Type: | type 17 immune cell |
| Experiment Type: | In vivo causal cis-regulatory deletion; TF-site dissection; Chromatin interaction assay |
| High Throughput Method: | ATAC-seq; scATAC-seq; CUT&Tag-seq; 4C-seq |
| Low Throughput Method: | 1001-bp endogenous CNS11 deletion; TF-motif mutation; bone-marrow chimera; flow cytometry; RT-qPCR |
About Target Gene
| Target gene : | Rorc |
About TF
| TF name : | Runx3 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Runx3 | Regulation of nuclear SMAD2/3 signaling | pid | 82 |
| Runx3 | TGF_beta_Receptor | netpath | 220 |
| Runx3 | Hs_TYROBP_Causal_Network_WP3945_90843 | wikipathways | 54 |
| Runx3 | Hs_Sudden_Infant_Death_Syndrome_(SIDS)_Susceptibility_Pathways_WP706_86078 | wikipathways | 33 |
Enhancer Associated Network
Overlapping Enhancers (mm39)
12 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_02392 | chr3:94294960-94295960 | small intestine | type 17 immune cell | NA |
| E_02394 | chr3:94294960-94295960 | small intestine | type 17 immune cell | NA |
| E_03196 | chr3:94294960-94295960 | small intestine | T-helper 17 cell | NA |
| E_03197 | chr3:94294960-94295960 | small intestine | T-helper 17 cell | NA |
| E_03198 | chr3:94294960-94295960 | small intestine | T-helper 17 cell | NA |
| E_03199 | chr3:94294960-94295960 | small intestine | T-helper 17 cell | NA |
| E_03219 | chr3:94294960-94295960 | small intestine | T-helper 17 cell | NA |
| E_03220 | chr3:94294960-94295960 | small intestine | T-helper 17 cell | NA |
| E_03221 | chr3:94294960-94295960 | small intestine | T-helper 17 cell | NA |
| E_03222 | chr3:94294960-94295960 | small intestine | T-helper 17 cell | NA |
| E_03223 | chr3:94294960-94295960 | small intestine | T-helper 17 cell | NA |
| E_03224 | chr3:94294960-94295960 | small intestine | T-helper 17 cell | NA |
Expression of Target Genes for the Enhancer