About Enhancer
| Enhancer ID: | E_02388 |
| Species: | Mus musculus |
| Position : | chr6:88093745-88094001   |
| Year: | 2021 |
| Title: | Gata2 -77 enhancer regulates adult hematopoietic stem cell survival. |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 32594099 |
| Tissue: | bone marrow |
| Tissue Ontology ID: | UBERON:0002371 |
| Cell Source: | Primary Mouse Bone Marrow Cells |
| Cell Type: | mouse bone marrow cell |
| Experiment Type: | Functional perturbation assay, TF binding assay, Chromatin interaction assay |
| High Throughput Method: | RNA-seq; ChIP-seq |
| Low Throughput Method: | CRISPR Knockout; RT-RT-qPCR, 3C Assay |
About Target Gene
| Target gene : | Gata2 |
About TF
| TF name : | Gata2 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Gata2 | AP-1 transcription factor network | pid | 71 |
| Gata2 | Factors involved in megakaryocyte development and platelet production | reactome | 111 |
| Gata2 | HIF-1-alpha transcription factor network | pid | 67 |
| Gata2 | IL3 | netpath | 84 |
| Gata2 | Regulation of Androgen receptor activity | pid | 54 |
| Gata2 | Signaling events mediated by HDAC Class I | pid | 89 |
| Gata2 | Signaling events mediated by HDAC Class II | pid | 58 |
| Gata2 | Hs_Apoptosis_WP254_88977 | wikipathways | 31 |
Enhancer Associated Network
Overlapping Enhancers (mm10)
No overlapping enhancers found in mm10 at this locus.
Expression of Target Genes for the Enhancer