About Enhancer
| Enhancer ID: | E_02380 |
| Species: | Mus musculus |
| Position : | chr17:44819323-44819541   |
| Year: | 2011 |
| Title: | Conserved regulatory motifs in osteogenic gene promoters integrate cooperative effects of canonical Wnt and BMP pathways. |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 20878775 |
| Tissue: | bone element |
| Tissue Ontology ID: | UBERON:0001474 |
| Cell Source: | MC3T3-E1 |
| CVCL ID: | CVCL_0409 |
| Cell Type: | osteoblast |
| Cell Ontology ID: | CL:0000062 |
| Experiment Type: | Enhancer activity assay, TF binding assay |
| Low Throughput Method: | Luciferase Reporter Assay, ChIP-RT-qPCR, RT-RT-qPCR, Western blot |
About Target Gene
| Target gene : | Runx2 |
About TF
| TF name : | Tcf4 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Tcf4 | AndrogenReceptor | netpath | 167 |
| Tcf4 | CDO in myogenesis | reactome | 29 |
| Tcf4 | Coregulation of Androgen receptor activity | pid | 61 |
| Tcf4 | Formation of the beta-catenin:TCF transactivating complex | reactome | 88 |
| Tcf4 | ID | netpath | 38 |
| Tcf4 | Regulation of nuclear beta catenin signaling and target gene transcription | pid | 80 |
| Tcf4 | TGF_beta_Receptor | netpath | 220 |
| Tcf4 | Wnt | netpath | 118 |
| Tcf4 | Hs_Corticotropin-releasing_hormone_signaling_pathway_WP2355_90017 | wikipathways | 41 |
Enhancer Associated Network
Overlapping Enhancers (mm10)
5 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_02375 | chr17:44819323-44819541 | skeletal muscle tissue | myoblast | NA |
| E_02376 | chr17:44819323-44819541 | bone element | osteoblast | NA |
| E_02377 | chr17:44819323-44819541 | skeletal muscle tissue | myoblast | NA |
| E_02378 | chr17:44819323-44819541 | bone element | osteoblast | NA |
| E_02379 | chr17:44819323-44819541 | skeletal muscle tissue | myoblast | NA |
Expression of Target Genes for the Enhancer