About Enhancer
| Enhancer ID: | E_02375 |
| Species: | Mus musculus |
| Position : | chr17:44819323-44819541   |
| Year: | 2011 |
| Title: | Conserved regulatory motifs in osteogenic gene promoters integrate cooperative effects of canonical Wnt and BMP pathways. |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 20878775 |
| Tissue: | skeletal muscle tissue |
| Tissue Ontology ID: | UBERON:0001134 |
| Cell Source: | C2C12 |
| CVCL ID: | CVCL_0188 |
| Cell Type: | myoblast |
| Cell Ontology ID: | CL:0000056 |
| Experiment Type: | Enhancer activity assay, TF binding assay |
| Low Throughput Method: | Luciferase Reporter Assay, ChIP-RT-qPCR, RT-RT-qPCR, Western blot |
About Target Gene
| Target gene : | Runx2 |
About TF
| TF name : | Smad1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Smad1 | ALK1 signaling events | pid | 26 |
| Smad1 | ALK2 signaling events | pid | 11 |
| Smad1 | BMP receptor signaling | pid | 42 |
| Smad1 | BMP signaling pathway ( TGF-beta_BMP Diagram(MolecularVariation) ) | inoh | 34 |
| Smad1 | BMP2 signaling pathway(through Smad) ( TGF-beta_BMP Diagram(MolecularVariation) ) | inoh | 13 |
| Smad1 | ErbB1 downstream signaling | pid | 105 |
| Smad1 | Gene expression of smad6/7 by R-smad:smad4 ( TGF-beta_super_family_signaling_pathway(canonical) ) | inoh | 8 |
| Smad1 | Gene expression of smad7 by R-smad:smad4 ( TGF-beta_super_family_signaling_pathway(canonical) ) | inoh | 7 |
| Smad1 | Hedgehog | netpath | 39 |
| Smad1 | LIF signaling pathway ( LIF signaling(JAK1 JAK2 STAT3) ) | inoh | 10 |
| Smad1 | Negative regulation of (nuclear import of R-smad:smad4) in TGF beta super family signaling pathway ( TGF-beta_super_family_signaling_pathway(canonical) ) | inoh | 11 |
| Smad1 | Negative regulation of (transcription by R-smad:smad4) in TGF beta super family signaling pathway ( TGF-beta_super_family_signaling_pathway(canonical) ) | inoh | 21 |
| Smad1 | Notch | netpath | 76 |
| Smad1 | Signaling by BMP | reactome | 23 |
| Smad1 | TGF-beta signaling pathway | panther | 88 |
| Smad1 | TGF-beta_super_family_signaling_pathway(canonical) ( TGF-beta_BMP Diagram(MolecularVariation) ) | inoh | 51 |
| Smad1 | Wnt | netpath | 118 |
| Smad1 | Wnt signaling pathway | panther | 250 |
| Smad1 | TGF-beta signaling pathway | kegg | 82 |
| Smad1 | Hs_Integrated_Breast_Cancer_Pathway_WP1984_82941 | wikipathways | 122 |
| Smad1 | Hs_Neural_Crest_Differentiation_WP2064_79263 | wikipathways | 40 |
| Smad1 | Hs_Heart_Development_WP1591_90186 | wikipathways | 28 |
| Smad1 | Hs_Bone_Morphogenic_Protein_(BMP)_Signalling_and_Regulation_WP1425_86082 | wikipathways | 6 |
| Smad1 | Hs_G13_Signaling_Pathway_WP524_72112 | wikipathways | 18 |
| Smad1 | Hs_Mesodermal_Commitment_Pathway_WP2857_87780 | wikipathways | 47 |
Enhancer Associated Network
Overlapping Enhancers (mm10)
5 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_02376 | chr17:44819323-44819541 | bone element | osteoblast | NA |
| E_02377 | chr17:44819323-44819541 | skeletal muscle tissue | myoblast | NA |
| E_02378 | chr17:44819323-44819541 | bone element | osteoblast | NA |
| E_02379 | chr17:44819323-44819541 | skeletal muscle tissue | myoblast | NA |
| E_02380 | chr17:44819323-44819541 | bone element | osteoblast | NA |
Expression of Target Genes for the Enhancer