About Enhancer
| Enhancer ID: | E_02361 |
| Species: | Mus musculus |
| Position : | chr7:134136598-134137038   |
| Year: | 2016 |
| Title: | In Vivo Deletion of the Cebpa +37 kb Enhancer Markedly Reduces Cebpa mRNA in Myeloid Progenitors but Not in Non-Hematopoietic Tissues to Impair Granulopoiesis. |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 26937964 |
| Tissue: | bone marrow |
| Tissue Ontology ID: | UBERON:0002371 |
| Cell Source: | 32Dcl3 |
| CVCL ID: | CVCL_0119 |
| Cell Type: | myeloid progenitor cell |
| Experiment Type: | Enhancer activity assay; TF binding assay; Functional perturbation assay; In vivo enhancer deletion assay |
| High Throughput Method: | ChIP-seq |
| Low Throughput Method: | CRISPR-Cas9 Ets-site mutagenesis; conditional enhancer deletion; RT-qPCR; flow cytometry; colony-forming assay; transplantation assay |
About Target Gene
| Target gene : | Cebpa |
About TF
| TF name : | Runx1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Runx1 | AndrogenReceptor | netpath | 167 |
| Runx1 | Organic cation transport | reactome | 9 |
| Runx1 | RANKL | netpath | 84 |
| Runx1 | Regulation of nuclear SMAD2/3 signaling | pid | 82 |
| Runx1 | TGF_beta_Receptor | netpath | 220 |
| Runx1 | Validated transcriptional targets of deltaNp63 isoforms | pid | 47 |
| Runx1 | Pathways in cancer | kegg | 321 |
| Runx1 | Chronic myeloid leukemia | kegg | 69 |
| Runx1 | Acute myeloid leukemia | kegg | 53 |
Enhancer Associated Network
Overlapping Enhancers (mm10)
No overlapping enhancers found in mm10 at this locus.
Expression of Target Genes for the Enhancer