About Enhancer
| Enhancer ID: | E_02359 |
| Species: | Mus musculus |
| Position : | chr13:53476414-53476689   |
| Year: | 2011 |
| Title: | Conserved regulatory motifs in osteogenic gene promoters integrate cooperative effects of canonical Wnt and BMP pathways. |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 20878775 |
| Tissue: | skeletal muscle tissue |
| Tissue Ontology ID: | UBERON:0001134 |
| Cell Source: | C2C12 |
| CVCL ID: | CVCL_0188 |
| Cell Type: | myoblast |
| Cell Ontology ID: | CL:0000056 |
| Experiment Type: | Enhancer activity assay; TF binding assay; Functional perturbation assay |
| Low Throughput Method: | Luciferase reporter assay; TCF/LEF-site mutagenesis; ChIP-qPCR; RT-qPCR; dominant-negative TCF4 perturbation; BMP-2/Wnt3a stimulation; GST pull-down; co-immunoprecipitation |
About Target Gene
| Target gene : | Msx2 |
About TF
| TF name : | Tcf7l2 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Tcf7l2 | Alzheimer disease-presenilin pathway | panther | 98 |
| Tcf7l2 | Angiogenesis | panther | 141 |
| Tcf7l2 | AP-1 transcription factor network | pid | 71 |
| Tcf7l2 | Binding of TCF/LEF:CTNNB1 to target gene promoters | reactome | 7 |
| Tcf7l2 | Ca2+ pathway | reactome | 62 |
| Tcf7l2 | Cadherin signaling pathway | panther | 147 |
| Tcf7l2 | Canonical Wnt signaling pathway ( C. elegans endoderm induction Wnt signaling pathway Diagram ) | inoh | 56 |
| Tcf7l2 | Canonical Wnt signaling pathway ( Canonical Wnt signaling pathway Diagram ) | inoh | 56 |
| Tcf7l2 | Canonical Wnt signaling pathway ( Drosophila Wingless/Wnt signaling pathway Diagram ) | inoh | 56 |
| Tcf7l2 | Canonical Wnt signaling pathway ( Mammalian Wnt signaling pathway Diagram ) | inoh | 56 |
| Tcf7l2 | Canonical Wnt signaling pathway ( Xenopus axis formation Wnt signaling pathway Diagram ) | inoh | 56 |
| Tcf7l2 | Deactivation of the beta-catenin transactivating complex | reactome | 42 |
| Tcf7l2 | Formation of the beta-catenin:TCF transactivating complex | reactome | 88 |
| Tcf7l2 | ID | netpath | 38 |
| Tcf7l2 | Mammalian Wnt signaling pathway ( Mammalian Wnt signaling pathway Diagram ) | inoh | 49 |
| Tcf7l2 | Regulation of nuclear beta catenin signaling and target gene transcription | pid | 80 |
| Tcf7l2 | Repression of WNT target genes | reactome | 14 |
| Tcf7l2 | Signaling with Wnt (Canonical) ( C. elegans endoderm induction Wnt signaling pathway Diagram ) | inoh | 47 |
| Tcf7l2 | Signaling with Wnt (Canonical) ( Canonical Wnt signaling pathway Diagram ) | inoh | 47 |
| Tcf7l2 | Signaling with Wnt (Canonical) ( Drosophila Wingless/Wnt signaling pathway Diagram ) | inoh | 47 |
| Tcf7l2 | Signaling with Wnt (Canonical) ( Mammalian Wnt signaling pathway Diagram ) | inoh | 47 |
| Tcf7l2 | Signaling with Wnt (Canonical) ( Xenopus axis formation Wnt signaling pathway Diagram ) | inoh | 47 |
| Tcf7l2 | Signaling with Wnt (Mammal) ( Mammalian Wnt signaling pathway Diagram ) | inoh | 47 |
| Tcf7l2 | Signaling with Wnt (Xenopus) ( Xenopus axis formation Wnt signaling pathway Diagram ) | inoh | 19 |
| Tcf7l2 | Signaling without Wnt (Canonical) ( C. elegans endoderm induction Wnt signaling pathway Diagram ) | inoh | 8 |
| Tcf7l2 | Signaling without Wnt (Canonical) ( Canonical Wnt signaling pathway Diagram ) | inoh | 8 |
| Tcf7l2 | Signaling without Wnt (Canonical) ( Drosophila Wingless/Wnt signaling pathway Diagram ) | inoh | 8 |
| Tcf7l2 | Signaling without Wnt (Canonical) ( Mammalian Wnt signaling pathway Diagram ) | inoh | 8 |
| Tcf7l2 | Signaling without Wnt (Canonical) ( Xenopus axis formation Wnt signaling pathway Diagram ) | inoh | 8 |
| Tcf7l2 | Signaling without Wnt (Mammal) ( Mammalian Wnt signaling pathway Diagram ) | inoh | 8 |
| Tcf7l2 | Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) | reactome | 20 |
| Tcf7l2 | Wnt | netpath | 118 |
| Tcf7l2 | Wnt signaling pathway | panther | 250 |
| Tcf7l2 | Wnt signaling pathway | kegg | 135 |
| Tcf7l2 | Adherens junction | kegg | 70 |
| Tcf7l2 | Melanogenesis | kegg | 100 |
| Tcf7l2 | Pathways in cancer | kegg | 321 |
| Tcf7l2 | Colorectal cancer | kegg | 63 |
| Tcf7l2 | Endometrial cancer | kegg | 52 |
| Tcf7l2 | Prostate cancer | kegg | 85 |
| Tcf7l2 | Acute myeloid leukemia | kegg | 53 |
| Tcf7l2 | Arrhythmogenic right ventricular cardiomyopathy (ARVC) | kegg | 71 |
Enhancer Associated Network
Expression of Target Genes for the Enhancer