About Enhancer
| Enhancer ID: | E_02354 |
| Species: | Mus musculus |
| Position : | chr7:35156536-35156974   |
| Year: | 2016 |
| Title: | In Vivo Deletion of the Cebpa +37 kb Enhancer Markedly Reduces Cebpa mRNA in Myeloid Progenitors but Not in Non-Hematopoietic Tissues to Impair Granulopoiesis. |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 26937964 |
| Tissue: | bone marrow |
| Tissue Ontology ID: | UBERON:0002371 |
| Cell Source: | Primary mouse myeloid progenitors |
| Cell Type: | myeloid progenitor cell |
| Experiment Type: | Enhancer activity assay; TF binding assay; Functional perturbation assay |
| High Throughput Method: | ChIP-seq evidence integration |
| Low Throughput Method: | Cre-loxP in vivo enhancer deletion; enhancer reporter mutagenesis; EMSA; RT-qPCR; flow cytometry; colony-forming assay; transplantation assay; CRISPR-Cas9 |
About Target Gene
| Target gene : | Cebpa |
About TF
| TF name : | Spi1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Spi1 | C-MYB transcription factor network | pid | 87 |
| Spi1 | ERK cascade ( FGF8 signaling (Mouse) ) | inoh | 17 |
| Spi1 | ERK cascade ( FGF8 signaling (Xenopus) ) | inoh | 17 |
| Spi1 | FGF8 signaling pathway(Mouse) ( FGF8 signaling (Mouse) ) | inoh | 20 |
| Spi1 | FGF8 signaling pathway(Xenopus) ( FGF8 signaling (Xenopus) ) | inoh | 18 |
| Spi1 | Glucocorticoid receptor regulatory network | pid | 85 |
| Spi1 | IL4-mediated signaling events | pid | 66 |
| Spi1 | IL4 | netpath | 75 |
| Spi1 | Interleukin signaling pathway | panther | 86 |
| Spi1 | RANKL | netpath | 84 |
| Spi1 | Regulation of retinoblastoma protein | pid | 67 |
| Spi1 | Validated targets of C-MYC transcriptional repression | pid | 63 |
| Spi1 | Pathways in cancer | kegg | 321 |
| Spi1 | Acute myeloid leukemia | kegg | 53 |
| Spi1 | Hs_RANKL-RANK_(Receptor_activator_of_NFKB_(ligand))_Signaling_Pathway_WP2018_90016 | wikipathways | 26 |
Enhancer Associated Network
Overlapping Enhancers (mm10)
40 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_02367 | chr7:35156353-35161233 | blood / hematopoietic system | NA | NA |
| E_02313 | chr7:35156394-35156899 | bone marrow | myeloid progenitor cell | NA |
| E_02314 | chr7:35156394-35156899 | bone marrow | myeloid progenitor cell | NA |
| E_02315 | chr7:35156394-35156899 | bone marrow | myeloid progenitor cell | NA |
| E_02316 | chr7:35156394-35156899 | bone marrow | myeloid progenitor cell | NA |
| E_02317 | chr7:35156394-35156899 | bone marrow | myeloid progenitor cell | NA |
| E_02318 | chr7:35156394-35156899 | bone marrow | myeloid progenitor cell | NA |
| E_00754 | chr7:35156536-35156974 | liver | hematopoietic multipotent progenitor cell | NA |
| E_01544 | chr7:35156536-35156974 | bone marrow | common myeloid progenitor / myeloid progenitor cell | NA |
| E_01545 | chr7:35156536-35156974 | bone marrow | common myeloid progenitor / myeloid progenitor cell | NA |
| E_01546 | chr7:35156536-35156974 | bone marrow | common myeloid progenitor / myeloid progenitor cell | NA |
| E_01547 | chr7:35156536-35156974 | bone marrow | common myeloid progenitor / myeloid progenitor cell | NA |
| E_01548 | chr7:35156536-35156974 | bone marrow | common myeloid progenitor / myeloid progenitor cell | NA |
| E_01549 | chr7:35156536-35156974 | bone marrow | common myeloid progenitor / myeloid progenitor cell | NA |
| E_01550 | chr7:35156536-35156974 | bone marrow | common myeloid progenitor / myeloid progenitor cell | NA |
| E_01551 | chr7:35156536-35156974 | bone marrow | common myeloid progenitor / myeloid progenitor cell | NA |
| E_01552 | chr7:35156536-35156974 | bone marrow | common myeloid progenitor / myeloid progenitor cell | NA |
| E_01572 | chr7:35156536-35156974 | bone marrow | common myeloid progenitor / myeloid progenitor cell | NA |
| E_01573 | chr7:35156536-35156974 | bone marrow | common myeloid progenitor / myeloid progenitor cell | NA |
| E_01574 | chr7:35156536-35156974 | bone marrow | common myeloid progenitor / myeloid progenitor cell | NA |
| E_01575 | chr7:35156536-35156974 | bone marrow | common myeloid progenitor / myeloid progenitor cell | NA |
| E_01576 | chr7:35156536-35156974 | bone marrow | common myeloid progenitor / myeloid progenitor cell | NA |
| E_01577 | chr7:35156536-35156974 | bone marrow | common myeloid progenitor / myeloid progenitor cell | NA |
| E_01578 | chr7:35156536-35156974 | bone marrow | common myeloid progenitor / myeloid progenitor cell | NA |
| E_01579 | chr7:35156536-35156974 | bone marrow | common myeloid progenitor / myeloid progenitor cell | NA |
| E_01580 | chr7:35156536-35156974 | bone marrow | common myeloid progenitor / myeloid progenitor cell | NA |
| E_02319 | chr7:35156536-35156974 | bone marrow | myeloid progenitor cell | NA |
| E_02320 | chr7:35156536-35156974 | bone marrow | myeloid progenitor cell | NA |
| E_02321 | chr7:35156536-35156974 | bone marrow | myeloid progenitor cell | NA |
| E_02322 | chr7:35156536-35156974 | bone marrow | myeloid progenitor cell | NA |
| E_02323 | chr7:35156536-35156974 | bone marrow | myeloid progenitor cell | NA |
| E_02324 | chr7:35156536-35156974 | bone marrow | myeloid progenitor cell | NA |
| E_02350 | chr7:35156536-35156974 | bone marrow | myeloid progenitor cell | NA |
| E_02351 | chr7:35156536-35156974 | bone marrow | myeloid progenitor cell | NA |
| E_02352 | chr7:35156536-35156974 | bone marrow | myeloid progenitor cell | NA |
| E_02353 | chr7:35156536-35156974 | bone marrow | myeloid progenitor cell | NA |
| E_02355 | chr7:35156536-35156974 | bone marrow | myeloid progenitor cell | NA |
| E_03361 | chr7:35156536-35156974 | bone marrow | myeloid progenitor cell | acute myeloid leukemia model |
| E_03375 | chr7:35156536-35156974 | bone marrow | common myeloid progenitor cell | acute myeloid leukemia model |
| E_03390 | chr7:35156536-35156974 | bone marrow | myeloid progenitor cell | acute myeloid leukemia |
Expression of Target Genes for the Enhancer