About Enhancer
| Enhancer ID: | E_02335 |
| Species: | Mus musculus |
| Position : | chr17:44494486-44495486   |
| Year: | 2011 |
| Title: | Conserved regulatory motifs in osteogenic gene promoters integrate cooperative effects of canonical Wnt and BMP pathways. |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 20878775 |
| Tissue: | blood / hematopoietic system |
| Tissue Ontology ID: | UBERON:0000178 |
| Cell Source: | C2C12,Primary Bone Marrow每Mesenchymal Stem Cell |
| Experiment Type: | Enhancer activity assay; TF-binding/chromatin assay; In vivo functional validation |
| Low Throughput Method: | Luciferase reporter assay; Reporter assay; ChIP-qPCR/ChIP; RT-qPCR/qPCR |
About Target Gene
| Target gene : | Runx2 |
About TF
| TF name : | Runx2 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Runx2 | AndrogenReceptor | netpath | 167 |
| Runx2 | FGF signaling pathway | pid | 55 |
| Runx2 | Leptin | netpath | 98 |
| Runx2 | Notch-mediated HES/HEY network | pid | 48 |
| Runx2 | Regulation of nuclear SMAD2/3 signaling | pid | 82 |
| Runx2 | Regulation of retinoblastoma protein | pid | 67 |
| Runx2 | TGF_beta_Receptor | netpath | 220 |
| Runx2 | YAP1- and WWTR1 (TAZ)-stimulated gene expression | reactome | 29 |
| Runx2 | Hs_MAPK_Signaling_Pathway_WP382_79951 | wikipathways | 58 |
| Runx2 | Hs_Endochondral_Ossification_WP474_87977 | wikipathways | 43 |
| Runx2 | Hs_Role_of_Osx_and_miRNAs_in_tooth_development_WP3971_91525 | wikipathways | 9 |
| Runx2 | Hs_Bone_Morphogenic_Protein_(BMP)_Signalling_and_Regulation_WP1425_86082 | wikipathways | 6 |
| Runx2 | Hs_Focal_Adhesion-PI3K-Akt-mTOR-signaling_pathway_WP3932_91101 | wikipathways | 8 |
Enhancer Associated Network
Overlapping Enhancers (mm10)
11 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_02331 | chr17:44494486-44495486 | blood / hematopoietic system | NA | NA |
| E_02332 | chr17:44494486-44495486 | blood / hematopoietic system | NA | NA |
| E_02333 | chr17:44494486-44495486 | blood / hematopoietic system | NA | NA |
| E_02334 | chr17:44494486-44495486 | blood / hematopoietic system | NA | NA |
| E_02336 | chr17:44494486-44495486 | blood / hematopoietic system | NA | NA |
| E_02337 | chr17:44494598-44494816 | blood / hematopoietic system | NA | NA |
| E_02338 | chr17:44494598-44494816 | blood / hematopoietic system | NA | NA |
| E_02339 | chr17:44494598-44494816 | blood / hematopoietic system | NA | NA |
| E_02340 | chr17:44494598-44494816 | blood / hematopoietic system | NA | NA |
| E_02341 | chr17:44494598-44494816 | blood / hematopoietic system | NA | NA |
| E_02342 | chr17:44494598-44494816 | blood / hematopoietic system | NA | NA |
Expression of Target Genes for the Enhancer