About Enhancer
| Enhancer ID: | E_02333 |
| Species: | Mus musculus |
| Position : | chr17:44494486-44495486   |
| Year: | 2011 |
| Title: | Conserved regulatory motifs in osteogenic gene promoters integrate cooperative effects of canonical Wnt and BMP pathways. |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 20878775 |
| Tissue: | blood / hematopoietic system |
| Tissue Ontology ID: | UBERON:0000178 |
| Cell Source: | C2C12,Primary Bone Marrow每Mesenchymal Stem Cell |
| Experiment Type: | Enhancer activity assay; TF-binding/chromatin assay; In vivo functional validation |
| Low Throughput Method: | Luciferase reporter assay; Reporter assay; ChIP-qPCR/ChIP; RT-qPCR/qPCR |
About Target Gene
| Target gene : | Runx2 |
About TF
| TF name : | Dlx5 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Dlx5 | Validated transcriptional targets of deltaNp63 isoforms | pid | 47 |
| Dlx5 | Hs_MECP2_and_Associated_Rett_Syndrome_WP3584_91190 | wikipathways | 12 |
| Dlx5 | Hs_Neural_Crest_Differentiation_WP2064_79263 | wikipathways | 40 |
Enhancer Associated Network
Overlapping Enhancers (mm10)
11 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_02331 | chr17:44494486-44495486 | blood / hematopoietic system | NA | NA |
| E_02332 | chr17:44494486-44495486 | blood / hematopoietic system | NA | NA |
| E_02334 | chr17:44494486-44495486 | blood / hematopoietic system | NA | NA |
| E_02335 | chr17:44494486-44495486 | blood / hematopoietic system | NA | NA |
| E_02336 | chr17:44494486-44495486 | blood / hematopoietic system | NA | NA |
| E_02337 | chr17:44494598-44494816 | blood / hematopoietic system | NA | NA |
| E_02338 | chr17:44494598-44494816 | blood / hematopoietic system | NA | NA |
| E_02339 | chr17:44494598-44494816 | blood / hematopoietic system | NA | NA |
| E_02340 | chr17:44494598-44494816 | blood / hematopoietic system | NA | NA |
| E_02341 | chr17:44494598-44494816 | blood / hematopoietic system | NA | NA |
| E_02342 | chr17:44494598-44494816 | blood / hematopoietic system | NA | NA |
Expression of Target Genes for the Enhancer