About Enhancer
| Enhancer ID: | E_02331 |
| Species: | Mus musculus |
| Position : | chr17:44494486-44495486   |
| Year: | 2011 |
| Title: | Conserved regulatory motifs in osteogenic gene promoters integrate cooperative effects of canonical Wnt and BMP pathways. |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 20878775 |
| Tissue: | blood / hematopoietic system |
| Tissue Ontology ID: | UBERON:0000178 |
| Cell Source: | C2C12,Primary Bone Marrow每Mesenchymal Stem Cell |
| Experiment Type: | Enhancer activity assay; TF-binding/chromatin assay; In vivo functional validation |
| Low Throughput Method: | Luciferase reporter assay; Reporter assay; ChIP-qPCR/ChIP; RT-qPCR/qPCR |
About Target Gene
| Target gene : | Runx2 |
About TF
| TF name : | Atf4 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Atf4 | Apoptosis signaling pathway | panther | 104 |
| Atf4 | ATF4 activates genes | reactome | 25 |
| Atf4 | ATF6-alpha activates chaperone genes | reactome | 10 |
| Atf4 | Validated transcriptional targets of AP1 family members Fra1 and Fra2 | pid | 37 |
| Atf4 | MAPK signaling pathway | kegg | 264 |
| Atf4 | Protein processing in endoplasmic reticulum | kegg | 166 |
| Atf4 | Long-term potentiation | kegg | 67 |
| Atf4 | Neurotrophin signaling pathway | kegg | 126 |
| Atf4 | GnRH signaling pathway | kegg | 98 |
| Atf4 | Prostate cancer | kegg | 85 |
| Atf4 | Hs_VEGFA-VEGFR2_Signaling_Pathway_WP3888_90000 | wikipathways | 153 |
| Atf4 | Hs_White_fat_cell_differentiation_WP3946_90940 | wikipathways | 30 |
| Atf4 | Hs_One_Carbon_Metabolism_WP241_89671 | wikipathways | 14 |
Enhancer Associated Network
Overlapping Enhancers (mm10)
11 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_02332 | chr17:44494486-44495486 | blood / hematopoietic system | NA | NA |
| E_02333 | chr17:44494486-44495486 | blood / hematopoietic system | NA | NA |
| E_02334 | chr17:44494486-44495486 | blood / hematopoietic system | NA | NA |
| E_02335 | chr17:44494486-44495486 | blood / hematopoietic system | NA | NA |
| E_02336 | chr17:44494486-44495486 | blood / hematopoietic system | NA | NA |
| E_02337 | chr17:44494598-44494816 | blood / hematopoietic system | NA | NA |
| E_02338 | chr17:44494598-44494816 | blood / hematopoietic system | NA | NA |
| E_02339 | chr17:44494598-44494816 | blood / hematopoietic system | NA | NA |
| E_02340 | chr17:44494598-44494816 | blood / hematopoietic system | NA | NA |
| E_02341 | chr17:44494598-44494816 | blood / hematopoietic system | NA | NA |
| E_02342 | chr17:44494598-44494816 | blood / hematopoietic system | NA | NA |
Expression of Target Genes for the Enhancer