About Enhancer
| Enhancer ID: | E_02237 |
| Species: | Mus musculus |
| Position : | chrX:103628000-103668000   |
| Year: | 2023 |
| Title: | GATA transcription factors drive initial Xist upregulation after fertilization through direct activation of long-range enhancers. |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 37932452 |
| Tissue: | embryo |
| Tissue Ontology ID: | UBERON:0000922 |
| Cell Source: | female XEN cells |
| Cell Type: | extraembryonic endoderm cell |
| Experiment Type: | RE97 long-range enhancer TF-binding and in vivo functional validation; database working interval |
| High Throughput Method: | GATA6 CUT&Tag; H3K27ac CUT&Tag; RNA-seq; ATAC-seq |
| Low Throughput Method: | FIREWACh enhancer reporter assay; zygotic CRISPR/Cas9 RE79/RE97 deletion; RNA-FISH |
About Target Gene
| Target gene : | Xist |
About TF
| TF name : | Gata6 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Gata6 | Factors involved in megakaryocyte development and platelet production | reactome | 111 |
| Gata6 | Notch-mediated HES/HEY network | pid | 48 |
| Gata6 | POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation | reactome | 10 |
| Gata6 | Surfactant metabolism | reactome | 30 |
| Gata6 | Hs_Endoderm_Differentiation_WP2853_88152 | wikipathways | 62 |
Enhancer Associated Network
Overlapping Enhancers (mm10)
1 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_02236 | chrX:103628000-103668000 | embryo | trophoblast stem cell | NA |
Expression of Target Genes for the Enhancer