About Enhancer
| Enhancer ID: | E_02236 |
| Species: | Mus musculus |
| Position : | chrX:103628000-103668000   |
| Year: | 2023 |
| Title: | GATA transcription factors drive initial Xist upregulation after fertilization through direct activation of long-range enhancers. |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 37932452 |
| Tissue: | embryo |
| Tissue Ontology ID: | UBERON:0000922 |
| Cell Source: | female trophoblast stem cells |
| Cell Type: | trophoblast stem cell |
| Experiment Type: | RE97 long-range enhancer TF-binding and in vivo functional validation; database working interval |
| High Throughput Method: | GATA3 CUT&Tag; H3K27ac CUT&Tag; RNA-seq; ATAC-seq |
| Low Throughput Method: | FIREWACh enhancer reporter assay; zygotic CRISPR/Cas9 RE79/RE97 deletion; RNA-FISH |
About Target Gene
| Target gene : | Xist |
About TF
| TF name : | Gata3 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Gata3 | C-MYB transcription factor network | pid | 87 |
| Gata3 | Calcineurin-regulated NFAT-dependent transcription in lymphocytes | pid | 50 |
| Gata3 | Factors involved in megakaryocyte development and platelet production | reactome | 111 |
| Gata3 | Glucocorticoid receptor regulatory network | pid | 85 |
| Gata3 | IL27-mediated signaling events | pid | 26 |
| Gata3 | Notch signaling pathway | pid | 58 |
| Gata3 | Regulation of nuclear SMAD2/3 signaling | pid | 82 |
| Gata3 | Hs_Endochondral_Ossification_WP474_87977 | wikipathways | 43 |
| Gata3 | Hs_White_fat_cell_differentiation_WP3946_90940 | wikipathways | 30 |
Enhancer Associated Network
Overlapping Enhancers (mm10)
1 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_02237 | chrX:103628000-103668000 | embryo | extraembryonic endoderm cell | NA |
Expression of Target Genes for the Enhancer