About Enhancer
| Enhancer ID: | E_02226 |
| Species: | Mus musculus |
| Position : | chrX:103578000-103588000   |
| Year: | 2023 |
| Title: | GATA transcription factors drive initial Xist upregulation after fertilization through direct activation of long-range enhancers. |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 37932452 |
| Tissue: | embryo |
| Tissue Ontology ID: | UBERON:0000922 |
| Cell Source: | female XEN cells |
| Cell Type: | extraembryonic endoderm cell |
| Experiment Type: | RE79 long-range enhancer TF-binding validation; database working interval |
| High Throughput Method: | GATA4 CUT&Tag; H3K27ac CUT&Tag; RNA-seq; ATAC-seq |
| Low Throughput Method: | FIREWACh enhancer reporter assay; zygotic CRISPR/Cas9 RE79/RE97 deletion; RNA-FISH |
About Target Gene
| Target gene : | Xist |
About TF
| TF name : | Gata4 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Gata4 | Factors involved in megakaryocyte development and platelet production | reactome | 111 |
| Gata4 | Notch-mediated HES/HEY network | pid | 48 |
| Gata4 | Physiological factors | reactome | 12 |
| Gata4 | Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) | reactome | 13 |
| Gata4 | YAP1- and WWTR1 (TAZ)-stimulated gene expression | reactome | 29 |
| Gata4 | Hs_Endoderm_Differentiation_WP2853_88152 | wikipathways | 62 |
| Gata4 | Hs_Heart_Development_WP1591_90186 | wikipathways | 28 |
| Gata4 | Hs_Serotonin_Receptor_2_and_ELK-SRF-GATA4_signaling_WP732_80010 | wikipathways | 13 |
Enhancer Associated Network
Overlapping Enhancers (mm10)
1 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_02175 | chrX:103578000-103588000 | embryo | embryonic stem cell | NA |
Expression of Target Genes for the Enhancer