Enhancer Detail

Comprehensive information about experimentally validated enhancers

About Enhancer
Enhancer ID: E_02167
Species: Mus musculus
Position : chr5:75699926-75706926
Year: 2024
Title: TAD border deletion at the Kit locus causes tissue-specific ectopic activation of a neighboring gene.
Genome Build: mm10
Enhancer Type: Enhancer
Condition: Normal
PMID:  38806452
Tissue: zone of skin
Tissue Ontology ID: UBERON:0000014
Cell Source: Primary Melanocytes (Kit ?30k)
Cell Type: melanocyte
Cell Ontology ID: CL:0000148
Experiment Type: Chromatin interaction assay, Functional perturbation assay; Endogenous enhancer perturbation; In vivo functional validation
High Throughput Method: Hi-C, RNA-seq, ChIP-seq
Low Throughput Method: CRISPR Knockout, qRT-PCR, Immunohistochemistry; CRISPR-Cas9 endogenous deletion/editing; Mouse genetic deletion/knock-in
About Target Gene
Target gene : Kdr
About TF
TF name : NA
About Regulatory State
Regulatory State : Active
Upstream Pathway Annotation of TF
GeneName Pathway Name Source Gene Number
Enhancer Associated Network
Overlapping Enhancers (mm10) 1 found
Enhancer ID Position Tissue Cell Disease
E_02169 chr5:75699926-75706926 bone marrow mast cell NA
Expression of Target Genes for the Enhancer