About Enhancer
| Enhancer ID: | E_02143 |
| Species: | Mus musculus |
| Position : | chr14:99319699-99358748   |
| Year: | 2025 |
| Title: | Klf5-adjacent super-enhancer functions as a 3D genome structure-dependent transcriptional driver to safeguard ESC identity. |
| Genome Build: | mm10 |
| Enhancer Type: | Super-enhancer |
| Condition: | Normal |
| PMID: | 40592854 |
| Tissue: | embryonic stem cell |
| Cell Source: | mouse embryonic stem cells |
| Cell Type: | embryonic stem cell |
| Cell Ontology ID: | CL:0002322 |
| Experiment Type: | Chromatin interaction assay |
| High Throughput Method: | 4C-seq; RNA-seq; single-cell RNA-seq; Hi-C |
| Low Throughput Method: | 3C-PCR; RT-qPCR |
About Target Gene
| Target gene : | Clybl |
About TF
| TF name : | Klf5 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Klf5 | Transcriptional regulation of white adipocyte differentiation | reactome | 79 |
| Klf5 | Hs_TGF-beta_Receptor_Signaling_WP560_90187 | wikipathways | 28 |
Enhancer Associated Network
Overlapping Enhancers (mm10)
7 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_02028 | chr14:99260419-99393893 | embryonic tissue | mouse embryonic stem cell | NA |
| E_02144 | chr14:99319699-99358748 | embryonic stem cell | embryonic stem cell | NA |
| E_02145 | chr14:99319699-99358748 | embryonic stem cell | embryonic stem cell | NA |
| E_02146 | chr14:99319699-99358748 | embryonic stem cell | embryonic stem cell | NA |
| E_01542 | chr14:99338943-99341862 | embryo | embryonic stem cell | NA |
| E_01562 | chr14:99338943-99341862 | embryo | primordial germ cell-like cell | NA |
| E_01563 | chr14:99338943-99341862 | embryo | epiblast-like cell | NA |
Expression of Target Genes for the Enhancer