Enhancer Detail

Comprehensive information about experimentally validated enhancers

About Enhancer
Enhancer ID: E_02133
Species: Mus musculus
Position : chrX:7583853-7584485
Year: 2026
Title: FOXP3 expression depends on cell-type-specific cis-regulatory elements and transcription factor circuitry.
Genome Build: mm10
Enhancer Type: Enhancer
Condition: Normal
PMID:  41237776
Tissue: blood / immune system
Tissue Ontology ID: UBERON:0000178
Cell Source: conventional CD4-positive T cells
Cell Type: T cell
Cell Ontology ID: CL:0000084
Experiment Type: Cis-regulatory element screen; Functional perturbation assay; TF-circuitry assay
High Throughput Method: CRISPR tiling screen; ATAC-seq; ChIP-seq/CUT&Tag; RNA-seq
Low Throughput Method: Targeted CRE perturbation; combinatorial CRISPRi; flow cytometry; RT-qPCR; murine CRE mutagenesis
About Target Gene
Target gene : Foxp3
About TF
TF name : NA
About Regulatory State
Regulatory State : Active
Upstream Pathway Annotation of TF
GeneName Pathway Name Source Gene Number
Enhancer Associated Network
Overlapping Enhancers (mm10) 3 found
Enhancer ID Position Tissue Cell Disease
E_04016 chrX:7230000-7720000 embryo mouse embryonic stem cell NA
E_02141 chrX:7583853-7584485 spleen regulatory T cell NA
E_02142 chrX:7583853-7584485 lymph node regulatory T cell NA
Expression of Target Genes for the Enhancer