About Enhancer
| Enhancer ID: | E_02115 |
| Species: | Mus musculus |
| Position : | chrX:7573447-7575334   |
| Year: | 2026 |
| Title: | FOXP3 expression depends on cell-type-specific cis-regulatory elements and transcription factor circuitry. |
| Genome Build: | mm10 |
| Enhancer Type: | Silencer |
| Condition: | Normal |
| PMID: | 41237776 |
| Tissue: | spleen |
| Tissue Ontology ID: | UBERON:0002106 |
| Cell Source: | Primary murine conventional CD4+ T cells |
| Cell Type: | CD4-positive, alpha-beta T cell |
| Cell Ontology ID: | CL:0000624 |
| Experiment Type: | Silencer activity assay; TF binding assay; Functional perturbation assay |
| High Throughput Method: | EGR2 ChIP-seq; H3K27ac ChIP-seq |
| Low Throughput Method: | Paired-Cas9 RNP tiled deletion; EGR2-motif-targeted CRISPR mutagenesis; FOXP3 flow cytometry; targeted amplicon sequencing |
About Target Gene
| Target gene : | Foxp3 |
About TF
| TF name : | Egr2 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Egr2 | Activation of anterior HOX genes in hindbrain development during early embryogenesis | reactome | 120 |
| Egr2 | Calcineurin-regulated NFAT-dependent transcription in lymphocytes | pid | 50 |
| Egr2 | IL4-mediated signaling events | pid | 66 |
| Egr2 | Transcriptional regulation of white adipocyte differentiation | reactome | 79 |
| Egr2 | Validated transcriptional targets of TAp63 isoforms | pid | 54 |
| Egr2 | Hs_Fatty_Acid_Beta_Oxidation_WP143_79783 | wikipathways | 14 |
Enhancer Associated Network
Expression of Target Genes for the Enhancer