About Enhancer
| Enhancer ID: | E_02104 |
| Species: | Mus musculus |
| Position : | chr2:73389900-73390100   |
| Year: | 2020 |
| Title: | HOX paralogs selectively convert binding of ubiquitous transcription factors into tissue-specific patterns of enhancer activation. |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 33315856 |
| Tissue: | pharyngeal arch |
| Tissue Ontology ID: | UBERON:0002539 |
| Cell Source: | NIH 3T3 |
| CVCL ID: | CVCL_0594 |
| Cell Type: | fibroblast |
| Cell Ontology ID: | CL:0000057 |
| Experiment Type: | Enhancer activity assay, TF binding assay; In vivo functional validation |
| High Throughput Method: | ChIP-seq |
| Low Throughput Method: | Luciferase Reporter Assay, Transgenic Reporter Assay, ChIP-RT-qPCR; In vivo phenotyping |
About Target Gene
| Target gene : | Meis2 |
About TF
| TF name : | Pbx1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Pbx1 | Activation of anterior HOX genes in hindbrain development during early embryogenesis | reactome | 120 |
| Pbx1 | Glucocorticoid receptor regulatory network | pid | 85 |
| Pbx1 | Transcriptional regulation of pluripotent stem cells | reactome | 28 |
Enhancer Associated Network
Overlapping Enhancers (mm10)
No overlapping enhancers found in mm10 at this locus.
Expression of Target Genes for the Enhancer