About Enhancer
| Enhancer ID: | E_02050 |
| Species: | Mus musculus |
| Position : | chr1:180924460-180925486   |
| Year: | 2024 |
| Title: | The cells are all-right: Regulation of the Lefty genes by separate enhancers in mouse embryonic stem cells. |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 39671433 |
| Tissue: | embryo |
| Tissue Ontology ID: | UBERON:0000922 |
| Cell Source: | Mouse embryonic stem |
| Cell Type: | mouse embryonic stem cell |
| Cell Ontology ID: | CL:0002322 |
| Experiment Type: | Enhancer activity assay, TF binding assay, Chromatin interaction assay, Functional perturbation assay |
| High Throughput Method: | ChIP-seq; RNA-seq; Hi-C |
| Low Throughput Method: | CRISPR Knockout; RT-RT-qPCR; CRISPR-Cas9 |
About Target Gene
| Target gene : | Lefty1 |
About TF
| TF name : | Klf4 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Klf4 | Regulation of nuclear beta catenin signaling and target gene transcription | pid | 80 |
| Klf4 | Synthesis, secretion, and deacylation of Ghrelin | reactome | 17 |
| Klf4 | Transcriptional regulation of pluripotent stem cells | reactome | 28 |
| Klf4 | Transcriptional regulation of white adipocyte differentiation | reactome | 79 |
| Klf4 | Hs_Role_of_Osx_and_miRNAs_in_tooth_development_WP3971_91525 | wikipathways | 9 |
| Klf4 | Hs_White_fat_cell_differentiation_WP3946_90940 | wikipathways | 30 |
| Klf4 | Hs_Mesodermal_Commitment_Pathway_WP2857_87780 | wikipathways | 47 |
Enhancer Associated Network
Overlapping Enhancers (mm10)
6 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_02048 | chr1:180924460-180925486 | embryo | mouse embryonic stem cell | NA |
| E_02049 | chr1:180924460-180925486 | embryo | mouse embryonic stem cell | NA |
| E_02051 | chr1:180924460-180925486 | embryo | mouse embryonic stem cell | NA |
| E_02052 | chr1:180924460-180925486 | embryo | mouse embryonic stem cell | NA |
| E_02053 | chr1:180924460-180925486 | embryo | mouse embryonic stem cell | NA |
| E_02054 | chr1:180924460-180925486 | embryo | mouse embryonic stem cell | NA |
Expression of Target Genes for the Enhancer