About Enhancer
| Enhancer ID: | E_02045 |
| Species: | Mus musculus |
| Position : | chr1:180887014-180889994   |
| Year: | 2024 |
| Title: | The cells are all-right: Regulation of the Lefty genes by separate enhancers in mouse embryonic stem cells. |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 39671433 |
| Tissue: | embryo |
| Tissue Ontology ID: | UBERON:0000922 |
| Cell Source: | Mouse embryonic stem |
| Cell Type: | mouse embryonic stem cell |
| Cell Ontology ID: | CL:0002322 |
| Experiment Type: | Enhancer activity assay, TF binding assay, Chromatin interaction assay, Functional perturbation assay |
| High Throughput Method: | ChIP-seq; RNA-seq; Hi-C |
| Low Throughput Method: | CRISPR Knockout; RT-RT-qPCR; CRISPR-Cas9 |
About Target Gene
| Target gene : | Lefty2 |
About TF
| TF name : | Sox2 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Sox2 | Deactivation of the beta-catenin transactivating complex | reactome | 42 |
| Sox2 | POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation | reactome | 13 |
| Sox2 | POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation | reactome | 10 |
| Sox2 | Transcriptional regulation of pluripotent stem cells | reactome | 28 |
| Sox2 | Hs_Endoderm_Differentiation_WP2853_88152 | wikipathways | 62 |
| Sox2 | Hs_Dopaminergic_Neurogenesis_WP2855_87239 | wikipathways | 19 |
| Sox2 | Hs_Wnt_Signaling_Pathway_and_Pluripotency_WP399_90291 | wikipathways | 12 |
| Sox2 | Hs_Mesodermal_Commitment_Pathway_WP2857_87780 | wikipathways | 47 |
| Sox2 | Hs_Ectoderm_Differentiation_WP2858_89329 | wikipathways | 56 |
Enhancer Associated Network
Overlapping Enhancers (mm10)
6 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_02041 | chr1:180887014-180889994 | embryo | mouse embryonic stem cell | NA |
| E_02042 | chr1:180887014-180889994 | embryo | mouse embryonic stem cell | NA |
| E_02043 | chr1:180887014-180889994 | embryo | mouse embryonic stem cell | NA |
| E_02044 | chr1:180887014-180889994 | embryo | mouse embryonic stem cell | NA |
| E_02046 | chr1:180887014-180889994 | embryo | mouse embryonic stem cell | NA |
| E_02047 | chr1:180887014-180889994 | embryo | mouse embryonic stem cell | NA |
Expression of Target Genes for the Enhancer