Enhancer Detail

Comprehensive information about experimentally validated enhancers

About Enhancer
Enhancer ID: E_02034
Species: Mus musculus
Position : chr8:28094779-28095609
Year: 2020
Title: HOX paralogs selectively convert binding of ubiquitous transcription factors into tissue-specific patterns of enhancer activation.
Genome Build: mm9
Enhancer Type: Enhancer
Condition: Normal
PMID:  33315856
Tissue: pharyngeal arch
Tissue Ontology ID: UBERON:0002539
Cell Source: NIH 3T3
CVCL ID: CVCL_0594
Cell Type: fibroblast
Cell Ontology ID: CL:0000057
Experiment Type: Enhancer activity assay; TF binding assay; Functional perturbation assay; In vivo functional validation
High Throughput Method: Hoxa2 ChIP-seq; Hoxa3 ChIP-seq; PBX ChIP-seq; MEIS ChIP-seq; H3K27ac ChIP-seq
Low Throughput Method: Luciferase Reporter Assay; ChIP-qPCR; HOX-PBX site-directed mutagenesis; In vivo phenotyping
About Target Gene
Target gene : Zfp703
About TF
TF name : Meis2
About Regulatory State
Regulatory State : Active
Upstream Pathway Annotation of TF
GeneName Pathway Name Source Gene Number
Enhancer Associated Network
Overlapping Enhancers (mm9) 2 found
Enhancer ID Position Tissue Cell Disease
E_02033 chr8:28094779-28095609 pharyngeal arch fibroblast NA
E_02095 chr8:28094779-28095609 pharyngeal arch fibroblast NA
Expression of Target Genes for the Enhancer