About Enhancer

Enhancer ID: E_01_0982
Species: human
Position : chr18:79393019-79395019
Biosample name:
Experiment class : High+Lowthroughput
Enhancer type: Enhancer
Disease: Myasthenia gravis
Pubmed ID:  32153563
Enhancer experiment: ELISAs
Enhancer experiment description: We also found binding sites for nuclear factor of activated T-cells (NFATC1), nuclear factor kappa-light-chain_x0002_enhancer of activated B cells (NF-?B), early growth response factor (EGR1), and the estrogen receptor 1 (ESR1).

About Target gene

Target gene : --
Strong evidence: qRT-PCR,qPCR,ChIP,3C
Less strong evidence: RNA-Seq
Target gene experiment description: We also found binding sites for nuclear factor of activated T-cells (NFATC1), nuclear factor kappa-light-chain_x0002_enhancer of activated B cells (NF-?B), early growth response factor (EGR1), and the estrogen receptor 1 (ESR1).

About TF

TF name : NFATC1(NF-ATC,NF-ATc1.2,NFAT2,NFATc)
TF experiment: ??????
TF experiment description: We also found binding sites for nuclear factor of activated T-cells (NFATC1), nuclear factor kappa-light-chain_x0002_enhancer of activated B cells (NF-?B), early growth response factor (EGR1), and the estrogen receptor 1 (ESR1).

About Function

Enhancer function : We also found binding sites for nuclear factor of activated T-cells (NFATC1), nuclear factor kappa-light-chain_x0002_enhancer of activated B cells (NF-?B), early growth response factor (EGR1), and the estrogen receptor 1 (ESR1).
Enhancer function experiment: Immunohistochemical staining
Enhancer function
experiment description:		 We also found binding sites for nuclear factor of activated T-cells (NFATC1), nuclear factor kappa-light-chain_x0002_enhancer of activated B cells (NF-?B), early growth response factor (EGR1), and the estrogen receptor 1 (ESR1).

About SNP

SNP ID: --

Upstream Pathway Annotation of TF

GeneName Pathway Name Source Gene Number
NFATC1 AP-1 transcription factor network pid 71
NFATC1 BCR signaling pathway pid 70
NFATC1 Ca2+ pathway reactome 62
NFATC1 Calcineurin-regulated NFAT-dependent transcription in lymphocytes pid 50
NFATC1 Calcium signaling in the CD4+ TCR pathway pid 29
NFATC1 CLEC7A (Dectin-1) induces NFAT activation reactome 13
NFATC1 Downstream signaling in nave CD8+ T cells pid 69
NFATC1 FCERI mediated Ca+2 mobilization reactome 41
NFATC1 Glucocorticoid receptor regulatory network pid 85
NFATC1 Inflammation mediated by chemokine and cytokine signaling pathway panther 189
NFATC1 RANKL netpath 84
NFATC1 Role of Calcineurin-dependent NFAT signaling in lymphocytes pid 54
NFATC1 Signaling by Wnt reactome 10
NFATC1 TCR netpath 261
NFATC1 Validated transcriptional targets of AP1 family members Fra1 and Fra2 pid 37
NFATC1 Wnt signaling pathway panther 250
NFATC1 Wnt signaling pathway kegg 135
NFATC1 Axon guidance kegg 126
NFATC1 VEGF signaling pathway kegg 70
NFATC1 Natural killer cell mediated cytotoxicity kegg 125
NFATC1 T cell receptor signaling pathway kegg 105
NFATC1 B cell receptor signaling pathway kegg 70
NFATC1 Hs_VEGFA-VEGFR2_Signaling_Pathway_WP3888_90000 wikipathways 153
NFATC1 Hs_TLR4_Signaling_and_Tolerance_WP3851_90114 wikipathways 8
NFATC1 Hs_T-Cell_antigen_Receptor_(TCR)_Signaling_Pathway_WP69_89937 wikipathways 60
NFATC1 Hs_RANKL-RANK_(Receptor_activator_of_NFKB_(ligand))_Signaling_Pathway_WP2018_90016 wikipathways 26

Enhancer associated network

The number on yellow line represents the distance between enhancer and target gene

Expression of target genes for the enhancer

Enhancer associated SNPs