About Enhancer
| Enhancer ID: | E_01_0967 |
| Species: | human |
| Position : | chr4:105142814-105144814   |
| Biosample name: | |
| Experiment class : | High+Lowthroughput |
| Enhancer type: | Enhancer |
| Disease: | -- |
| Pubmed ID: | 33057201 |
| Enhancer experiment: | PCR,RNA-seq |
| Enhancer experiment description: | In silico-informed in vitro evaluation of the TET2 germline locus enabled the identifcation of a causal variant that disrupts a TET2 distal enhancer, resulting in increased self-renewal of haematopoietic stem cells. |
About Target gene
| Target gene : | TET2(Ayu17-449,E130014J05Rik,mKIAA1546) |
| Strong evidence: | qRT-PCR,qPCR,ChIP,3C |
| Less strong evidence: | RNA-Seq |
| Target gene experiment description: | In silico-informed in vitro evaluation of the TET2 germline locus enabled the identifcation of a causal variant that disrupts a TET2 distal enhancer, resulting in increased self-renewal of haematopoietic stem cells. |
About TF
| TF name : | -- |
| TF experiment: | PCR,RNA-seq |
| TF experiment description: | In silico-informed in vitro evaluation of the TET2 germline locus enabled the identifcation of a causal variant that disrupts a TET2 distal enhancer, resulting in increased self-renewal of haematopoietic stem cells. |
About Function
| Enhancer function : | In silico-informed in vitro evaluation of the TET2 germline locus enabled the identifcation of a causal variant that disrupts a TET2 distal enhancer, resulting in increased self-renewal of haematopoietic stem cells. |
| Enhancer function experiment: | Immunohistochemical staining |
| Enhancer function experiment description: |
In silico-informed in vitro evaluation of the TET2 germline locus enabled the identifcation of a causal variant that disrupts a TET2 distal enhancer, resulting in increased self-renewal of haematopoietic stem cells. |
About SNP
| SNP ID: | rs13167280,rs1210060191 |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene