About Enhancer
| Enhancer ID: | E_01_0938 |
| Species: | human |
| Position : | chr12:57513827-57515827   |
| Biosample name: | |
| Experiment class : | High+Lowthroughput |
| Enhancer type: | Enhancer |
| Disease: | -- |
| Pubmed ID: | 32673756 |
| Enhancer experiment: | Western blotting |
| Enhancer experiment description: | Commonly associated with endoplasmic reticulum stress, the bZIP transcription factor CCAAT/enhancer-binding protein homologous protein (CHOP/DDIT3) mediates the cellular response to redox stress with effects on cellular growth, differentiation, and survival. |
About Target gene
| Target gene : | -- |
| Strong evidence: | qRT-PCR,qPCR,ChIP,3C |
| Less strong evidence: | RNA-Seq |
| Target gene experiment description: | Commonly associated with endoplasmic reticulum stress, the bZIP transcription factor CCAAT/enhancer-binding protein homologous protein (CHOP/DDIT3) mediates the cellular response to redox stress with effects on cellular growth, differentiation, and survival. |
About TF
| TF name : | DDIT3 |
| TF experiment: | Western blotting |
| TF experiment description: | Commonly associated with endoplasmic reticulum stress, the bZIP transcription factor CCAAT/enhancer-binding protein homologous protein (CHOP/DDIT3) mediates the cellular response to redox stress with effects on cellular growth, differentiation, and survival. |
About Function
| Enhancer function : | Commonly associated with endoplasmic reticulum stress, the bZIP transcription factor CCAAT/enhancer-binding protein homologous protein (CHOP/DDIT3) mediates the cellular response to redox stress with effects on cellular growth, differentiation, and survival. |
| Enhancer function experiment: | Immunohistochemical staining |
| Enhancer function experiment description: |
Commonly associated with endoplasmic reticulum stress, the bZIP transcription factor CCAAT/enhancer-binding protein homologous protein (CHOP/DDIT3) mediates the cellular response to redox stress with effects on cellular growth, differentiation, and survival. |
About SNP
| SNP ID: | -- |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| DDIT3 | ATF-2 transcription factor network | pid | 59 |
| DDIT3 | ATF4 activates genes | reactome | 25 |
| DDIT3 | ATF6-alpha activates chaperone genes | reactome | 10 |
| DDIT3 | Oxidative stress response | panther | 23 |
| DDIT3 | Signaling mediated by p38-alpha and p38-beta | pid | 35 |
| DDIT3 | Validated targets of C-MYC transcriptional repression | pid | 63 |
| DDIT3 | MAPK signaling pathway | kegg | 264 |
| DDIT3 | Protein processing in endoplasmic reticulum | kegg | 166 |
| DDIT3 | Hs_White_fat_cell_differentiation_WP3946_90940 | wikipathways | 30 |
| DDIT3 | Hs_Complement_and_Coagulation_Cascades_WP558_90196 | wikipathways | 21 |
| DDIT3 | Hs_Integrin-mediated_Cell_Adhesion_WP185_88160 | wikipathways | 38 |
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene