About Enhancer
| Enhancer ID: | E_01_0935 |
| Species: | human |
| Position : | chr12:7785139-7787139   |
| Biosample name: | |
| Experiment class : | High+Lowthroughput |
| Enhancer type: | Enhancer |
| Disease: | -- |
| Pubmed ID: | 32677466 |
| Enhancer experiment: | MeDIP-seq,RNA-seq,miRNA-seq |
| Enhancer experiment description: | Intersecting NPC core enhancers with TFBSs predicted by Homer [25] revealed 13 transcription factors significantly enriched (q < 0.01 and >20% enhancers with motif ) (Supplementary Figure 2), including the master regulators of pluripotency NANOG and SOX3, as well as key regulators of brain development such as LHX3, a transcription factor involved in the specification of motor neurons and interneurons |
About Target gene
| Target gene : | NANOG(NANOG) |
| Strong evidence: | qRT-PCR,qPCR,ChIP,3C |
| Less strong evidence: | RNA-Seq |
| Target gene experiment description: | Intersecting NPC core enhancers with TFBSs predicted by Homer [25] revealed 13 transcription factors significantly enriched (q < 0.01 and >20% enhancers with motif ) (Supplementary Figure 2), including the master regulators of pluripotency NANOG and SOX3, as well as key regulators of brain development such as LHX3, a transcription factor involved in the specification of motor neurons and interneurons;Intersecting NPC core enhancers with TFBSs predicted by Homer [25] revealed 13 transcription factors significantly enriched (q < 0.01 and >20% enhancers with motif ) (Supplementary Figure 2), including the master regulators of pluripotency NANOG and SOX3, as well as key regulators of brain development such as LHX3, a transcription factor involved in the specification of motor neurons and interneurons |
About TF
| TF name : | SOX3 |
| TF experiment: | MeDIP-seq,RNA-seq,miRNA-seq |
| TF experiment description: | Intersecting NPC core enhancers with TFBSs predicted by Homer [25] revealed 13 transcription factors significantly enriched (q < 0.01 and >20% enhancers with motif ) (Supplementary Figure 2), including the master regulators of pluripotency NANOG and SOX3, as well as key regulators of brain development such as LHX3, a transcription factor involved in the specification of motor neurons and interneurons;Intersecting NPC core enhancers with TFBSs predicted by Homer [25] revealed 13 transcription factors significantly enriched (q < 0.01 and >20% enhancers with motif ) (Supplementary Figure 2), including the master regulators of pluripotency NANOG and SOX3, as well as key regulators of brain development such as LHX3, a transcription factor involved in the specification of motor neurons and interneurons |
About Function
| Enhancer function : | Intersecting NPC core enhancers with TFBSs predicted by Homer [25] revealed 13 transcription factors significantly enriched (q < 0.01 and >20% enhancers with motif ) (Supplementary Figure 2), including the master regulators of pluripotency NANOG and SOX3, as well as key regulators of brain development such as LHX3, a transcription factor involved in the specification of motor neurons and interneurons |
| Enhancer function experiment: | Immunohistochemical staining |
| Enhancer function experiment description: |
Intersecting NPC core enhancers with TFBSs predicted by Homer [25] revealed 13 transcription factors significantly enriched (q < 0.01 and >20% enhancers with motif ) (Supplementary Figure 2), including the master regulators of pluripotency NANOG and SOX3, as well as key regulators of brain development such as LHX3, a transcription factor involved in the specification of motor neurons and interneurons |
About SNP
| SNP ID: | -- |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| SOX3 | Deactivation of the beta-catenin transactivating complex | reactome | 42 |
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene