About Enhancer
| Enhancer ID: | E_01_0930 |
| Species: | human |
| Position : | chr5:141399891-141401891   |
| Biosample name: | |
| Experiment class : | High+Lowthroughput |
| Enhancer type: | Enhancer |
| Disease: | Gastric cancer |
| Pubmed ID: | 32231199 |
| Enhancer experiment: | qRT-PCR,qPCR,western blotting |
| Enhancer experiment description: | Laser confocal techniques and western blotting revealed that PCDHGA9 inhibited the nuclear translocation of ?-catenin, regulated T cell factor (TCF)/ /lymphoid enhancer factor (LEF) transcriptional activity, directly impacted the signal transmission of the TGF-?/Smad2/3 pathway, strengthened the adhesion complex, weakened the effects of TGF-?, and blocked the activation of the Wnt pathway. |
About Target gene
| Target gene : | PCDHGA9 |
| Strong evidence: | qRT-PCR,qPCR,ChIP,3C |
| Less strong evidence: | RNA-Seq |
| Target gene experiment description: | Laser confocal techniques and western blotting revealed that PCDHGA9 inhibited the nuclear translocation of ?-catenin, regulated T cell factor (TCF)/ /lymphoid enhancer factor (LEF) transcriptional activity, directly impacted the signal transmission of the TGF-?/Smad2/3 pathway, strengthened the adhesion complex, weakened the effects of TGF-?, and blocked the activation of the Wnt pathway. |
About TF
| TF name : | -- |
| TF experiment: | qRT-PCR,qPCR,western blotting |
| TF experiment description: | Laser confocal techniques and western blotting revealed that PCDHGA9 inhibited the nuclear translocation of ?-catenin, regulated T cell factor (TCF)/ /lymphoid enhancer factor (LEF) transcriptional activity, directly impacted the signal transmission of the TGF-?/Smad2/3 pathway, strengthened the adhesion complex, weakened the effects of TGF-?, and blocked the activation of the Wnt pathway. |
About Function
| Enhancer function : | Laser confocal techniques and western blotting revealed that PCDHGA9 inhibited the nuclear translocation of ?-catenin, regulated T cell factor (TCF)/ /lymphoid enhancer factor (LEF) transcriptional activity, directly impacted the signal transmission of the TGF-?/Smad2/3 pathway, strengthened the adhesion complex, weakened the effects of TGF-?, and blocked the activation of the Wnt pathway. |
| Enhancer function experiment: | Immunohistochemical staining |
| Enhancer function experiment description: |
Laser confocal techniques and western blotting revealed that PCDHGA9 inhibited the nuclear translocation of ?-catenin, regulated T cell factor (TCF)/ /lymphoid enhancer factor (LEF) transcriptional activity, directly impacted the signal transmission of the TGF-?/Smad2/3 pathway, strengthened the adhesion complex, weakened the effects of TGF-?, and blocked the activation of the Wnt pathway. |
About SNP
| SNP ID: | -- |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene