ENdb-Search-Detail

About Enhancer

Enhancer ID:	E_01_0891
Species:	human
Position :	chr5:179803964-179805964
Biosample name:
Experiment class :	High+Lowthroughput
Enhancer type:	Enhancer
Disease:	Alzheimer disease
Pubmed ID:	31441382
Enhancer experiment:	Knockdown, Western blot, PCR, gel electrophoresis
Enhancer experiment description:	SQSTM1/p62 and PPARGC1A/PGC-1alpha at the interface of autophagy and vascular senescence.

Target gene :	SQSTM1
Strong evidence:	qRT-PCR,qPCR,ChIP,3C
Less strong evidence:	RNA-Seq
Target gene experiment description:	SQSTM1/p62 and PPARGC1A/PGC-1alpha at the interface of autophagy and vascular senescence.;SQSTM1/p62 and PPARGC1A/PGC-1alpha at the interface of autophagy and vascular senescence.

TF name :	PPARGC1A(A830037N07Rik,Gm11133,PGC-1,PPARGC-1-alpha,Pgc-1alpha,Pgc1,Pgco1,Ppargc1)
TF experiment:	????,Western blot,PCR,????
TF experiment description:	SQSTM1/p62 and PPARGC1A/PGC-1alpha at the interface of autophagy and vascular senescence.;SQSTM1/p62 and PPARGC1A/PGC-1alpha at the interface of autophagy and vascular senescence.

Enhancer function :	SQSTM1/p62 and PPARGC1A/PGC-1alpha at the interface of autophagy and vascular senescence.
Enhancer function experiment:	Immunohistochemical staining
Enhancer function experiment description:	SQSTM1/p62 and PPARGC1A/PGC-1alpha at the interface of autophagy and vascular senescence.

SNP ID:

GeneName	Pathway Name	Source	Gene Number
PPARGC1A	Activation of PPARGC1A (PGC-1alpha) by phosphorylation	reactome	10
PPARGC1A	ATF-2 transcription factor network	pid	59
PPARGC1A	BMAL1:CLOCK,NPAS2 activates circadian gene expression	reactome	42
PPARGC1A	Circadian Clock	reactome	49
PPARGC1A	mTOR signaling pathway	pid	66
PPARGC1A	PPARA activates gene expression	reactome	113
PPARGC1A	RORA activates gene expression	reactome	27
PPARGC1A	Signaling events mediated by HDAC Class III	pid	41
PPARGC1A	Signaling mediated by p38-alpha and p38-beta	pid	35
PPARGC1A	Transcriptional activation of mitochondrial biogenesis	reactome	43
PPARGC1A	Transcriptional regulation of white adipocyte differentiation	reactome	79
PPARGC1A	Insulin signaling pathway	kegg	134
PPARGC1A	Adipocytokine signaling pathway	kegg	65
PPARGC1A	Huntington's disease	kegg	182
PPARGC1A	Hs_Tryptophan_metabolism_WP465_85055	wikipathways	45
PPARGC1A	Hs_Osteoblast_Signaling_WP322_90527	wikipathways	10
PPARGC1A	Hs_Energy_Metabolism_WP1541_91584	wikipathways	13
PPARGC1A	Hs_Transcription_factor_regulation_in_adipogenesis_WP3599_88581	wikipathways	9
PPARGC1A	Hs_Mitochondrial_Gene_Expression_WP391_71373	wikipathways	11
PPARGC1A	Hs_Osteoclast_Signaling_WP12_88602	wikipathways	7
PPARGC1A	Hs_SREBF_and_miR33_in_cholesterol_and_lipid_homeostasis_WP2011_89947	wikipathways	6

The number on yellow line represents the distance between enhancer and target gene